Altered Maternal Plasma Fatty Acid Composition by Alcohol Consumption and Smoking during Pregnancy and Associations with Fetal Alcohol Spectrum Disorders
| Autor: | Wladimir Wertelecki, Roberta R. Holt, Julie A. Kable, Krista Sowell, Janet Y. Uriu-Adams, Claire D. Coles, Natalya Zymak-Zakutnya, Carl L. Keen, Lyubov Yevtushok, Christina D. Chambers |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Alcohol Drinking Maternal Health Pregnancy Trimester Third Medicine (miscellaneous) Gestational Age 030209 endocrinology & metabolism Alcohol Third trimester Article 03 medical and health sciences chemistry.chemical_compound Fetal alcohol 0302 clinical medicine Pregnancy Internal medicine medicine Birth Weight Humans Maternal Behavior chemistry.chemical_classification Fetus 030109 nutrition & dietetics Nutrition and Dietetics business.industry Fatty Acids Smoking Infant Newborn Prenatal smoking Endocrinology chemistry Fetal Alcohol Spectrum Disorders Neurodevelopmental Disorders Female Fatty acid composition Ukraine business Alcohol consumption Polyunsaturated fatty acid |
| Zdroj: | J Am Coll Nutr |
| ISSN: | 1541-1087 0731-5724 |
| DOI: | 10.1080/07315724.2020.1737984 |
| Popis: | OBJECTIVE: Polyunsaturated fatty acids are vital for optimal fetal neuronal development. The relationship between maternal alcohol consumption and smoking with third trimester plasma fatty acids were examined and their association with Fetal Alcohol Spectrum Disorders (FASD). Methods: Moderate to heavy alcohol-using and low/unexposed comparison women were recruited during mid-pregnancy from two prenatal clinics in Ukraine. The participants’ infants underwent physical and neurobehavioral exams prior to one-year of age and classified as having FASD by maternal alcohol consumption and neurobehavioral scores. A subset of mother-child pairs was selected representing three groups of cases and controls: Alcohol-Exposed with FASD (AE-FASD, n=30), Alcohol-Exposed Normally Developing (AE-ND, n=33), or Controls (n=46). Third trimester maternal plasma samples were analyzed for fatty acids and levels were compared across groups. RESULTS: The percent of C18:0 (p |
| Databáze: | OpenAIRE |
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