Anaphylactoid reaction to high-dose methotrexate and successful desensitization
| Autor: | Ignacio Oulego-Erroz, Manuel Vázquez-Donsión, Jose Miguel Couselo, Marta Bouzón-Alejandro, Mercedes Maneiro-Freire |
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| Rok vydání: | 2010 |
| Předmět: |
Antimetabolites
Antineoplastic Osteosarcoma Tibia business.industry medicine.medical_treatment Bone Neoplasms Hematology High dose methotrexate Methotrexate Oncology Desensitization Immunologic Anesthesia Pediatrics Perinatology and Child Health Medicine Humans Female Anaphylactoid reactions business Child Anaphylaxis Localized osteosarcoma medicine.drug Desensitization (medicine) |
| Zdroj: | Pediatric bloodcancer. 55(3) |
| ISSN: | 1545-5017 |
| Popis: | Anaphylactic/anaphylactoid reaction to methotrexate (MTX) is uncommon. It may occur with the first dose (non-allergic reactions) or after a previous exposure to the drug (allergic or specific reactions). Desensitization has been shown effective in children with allergic-type reactions permitting the continuation of high-dose methotrexate (HDMTX) therapy. We report the case of a child with localized osteosarcoma who developed an anaphylactoid reaction after a first HDMTX course. A desensitization protocol was successfully applied allowing the administration of four additional courses. In our experience, desensitization can be a safe and effective procedure in children with anaphylactoid reactions to HDMTX. |
| Databáze: | OpenAIRE |
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