Synergistic Effects of Fish Oil Diet and Dimethylthiourea in Acute Adriamycin Nephrosis
| Autor: | Mark T. Houser, Shu Wei, Lawrence S. Milner, Peter Kazakoff, Leroy Watkins |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
Time Factors Thromboxane medicine.medical_treatment Kidney Oenothera biennis Rats Sprague-Dawley Random Allocation chemistry.chemical_compound Fish Oils Reference Values Internal medicine Hyperlipidemia medicine Animals Plant Oils gamma-Linolenic Acid Triglycerides Hypolipidemic Agents Fatty Acids Essential business.industry Thiourea General Medicine Glutathione Fish oil Free radical scavenger medicine.disease Dietary Fats Rats Proteinuria Cholesterol Endocrinology Linoleic Acids chemistry Doxorubicin Toxicity Nephrosis Drug Therapy Combination Corn Oil business Corn oil Prostaglandin E |
| Zdroj: | The American Journal of the Medical Sciences. 308:266-270 |
| ISSN: | 0002-9629 |
| DOI: | 10.1097/00000441-199411000-00002 |
| Popis: | The synergistic effects of combining fish oil (FO) diet, which reduces thromboxane A production, with the free radical scavenger, dimethylthiourea (DMTU), were evaluated in acute adriamycin nephrosis, because proteinuria in adriamycin nephrosis is mediated by increased renal thromboxane A and free radical production. The effects of combined evening primrose oil (EPO) and DMTU were compared with the DMTU + FO combination because EPO increases prostaglandin E but not thromboxane A. After 7, 14, and 21 days, proteinuria was significantly (p < 0.05) reduced in rats receiving either DMTU + corn oil (CO) or DMTU + FO compared with untreated control rats. However, after 21 days, rats receiving DMTU + FO had significantly reduced urine protein excretion compared with those receiving DMTU + CO (103.9 ± 20 mg daily vs 351.8 ± 29.8 mg daily; P < 0.05). In contrast to FO, rats receiving EPO + DMTU had similar urine protein excretion to rats receiving DMTU + CO after 21 days (170.2 ± 20.34 mg daily vs 179.45 ± 26.38 mg daily). The mean serum cholesterol concentration was significantly (P < 0.01) reduced in rats receiving DMTU + FO (195.2 ± 23.8 mg/dL) compared with DMTU + CO (377.9 ± 28.5 mg/dL). Serum triglyceride levels also were significantly (P < 0.01) reduced in rats receiving DMTU + FO (52.5 ± 26.4 mg/dL) compared with DMTU + CO (100.5 ± 36.9 mg/dL). No significant differences in serum cholesterol concentrations or triglycerides occurred between rats receiving DMTU + CO and DMTU + EPO. Renal glutathione content was significantly (P < 0.05) increased by 23% in normal rats receiving FO diet and by 34% in rats receiving combined DMTU + FO compared with CO alone. Evening primrose oil did not enhance renal glutathione content. The authors conclude that FO diet, but not EPO, is synergistic with DMTU in reducing proteinuria and hyperlipidemia in adriamycin nephrosis, possibly by enhancing the free radical scavenging ability of DMTU. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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