A retrospective study on the efficacy and safety of amphotericin B in a lipid emulsion for the treatment of cryptococcal meningitis in AIDS patients
| Autor: | Filippo Speranza, M. Airoldi, C Zeroli, Roberto Tambini, R Martegani, Donato Torre, Giuseppe Banfi, G. P. Fiori |
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| Rok vydání: | 1998 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty Fat Emulsions Intravenous Antifungal Agents Opportunistic infection Meningitis Cryptococcal Nephrotoxicity Internal medicine Amphotericin B Medicine Humans Adverse effect Mycosis Retrospective Studies AIDS-Related Opportunistic Infections business.industry Retrospective cohort study medicine.disease Surgery Infectious Diseases Treatment Outcome Cryptococcosis Female business Meningitis medicine.drug |
| Zdroj: | The Journal of infection. 37(1) |
| ISSN: | 0163-4453 |
| Popis: | To evaluate the efficacy and safety of Amphotericin B dissolved in dextrose (Amb) or in a lipid emulsion (Intralipid, Amb-IL) in AIDS patients with cryptococcal meningitis, we conducted a retrospective study in 30 AIDS patients with cryptococcal meningitis. A clinical complete resolution was obtained in 11 patients (55%) treated with Amb, and in six patients (60%) treated with Amb-IL. Intralipid did not decrease the infusion-related adverse effects, in particular nephrotoxicity and anaemia. Our results indicate that Amb-IL formulation is useful in the treatment of cryptococcal meningitis in AIDS patients, but it does not reduce the infusion-related adverse events. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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