Carbon nanomaterials for cardiovascular theranostics: Promises and challenges
| Autor: | Sajitha Mathan, Alireza Rafieerad, Weiang Yan, Hanna Manego, Saravanan Sekaran, Sanjiv Dhingra, Keshav Narayan Alagarsamy |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Engineering
QH301-705.5 0206 medical engineering Biomedical Engineering Nanotechnology 02 engineering and technology Carbon nanotube Cardiac tissue engineering Article law.invention Biomaterials Immunomodulation law Mechanical strength Tissue damage Biology (General) Materials of engineering and construction. Mechanics of materials Carbon nanomaterials business.industry Treatment options Tissue repair 021001 nanoscience & nanotechnology Cardiovascular disease 020601 biomedical engineering Bench to bedside 3. Good health Biosensors 13. Climate action Drug delivery TA401-492 0210 nano-technology business Biotechnology |
| Zdroj: | Bioactive Materials, Vol 6, Iss 8, Pp 2261-2280 (2021) Bioactive Materials |
| Popis: | Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Heart attack and stroke cause irreversible tissue damage. The currently available treatment options are limited to “damage-control” rather than tissue repair. The recent advances in nanomaterials have offered novel approaches to restore tissue function after injury. In particular, carbon nanomaterials (CNMs) have shown significant promise to bridge the gap in clinical translation of biomaterial based therapies. This family of carbon allotropes (including graphenes, carbon nanotubes and fullerenes) have unique physiochemical properties, including exceptional mechanical strength, electrical conductivity, chemical behaviour, thermal stability and optical properties. These intrinsic properties make CNMs ideal materials for use in cardiovascular theranostics. This review is focused on recent efforts in the diagnosis and treatment of heart diseases using graphenes and carbon nanotubes. The first section introduces currently available derivatives of graphenes and carbon nanotubes and discusses some of the key characteristics of these materials. The second section covers their application in drug delivery, biosensors, tissue engineering and immunomodulation with a focus on cardiovascular applications. The final section discusses current shortcomings and limitations of CNMs in cardiovascular applications and reviews ongoing efforts to address these concerns and to bring CNMs from bench to bedside. Graphical abstract Image 1 Highlights • Unique properties of the carbon nanomaterials (CNM) for cardiovascular theranostics. • Applications of CNMs for cardiovascular medicine as drug carriers, biosensors, cardiac tissue engineering constructs and immunomodulation. • Limitations of CNMs in cardiovascular theranostics applications. • Strategies to mitigate the challenges to bring CNMs from bench to bedside for cardiovascular theranostics. |
| Databáze: | OpenAIRE |
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