Synthesis, characterization and biological activity of Hg(II), Fe(III) complexes with 1,3,4-oxadiazole, 1,2,4-triazole derivatives from L-methionine
| Autor: | Adil Ali Othman, Khaled Briki, Mouna Souad Abbassi, Mokhtar Boualem Lahrech |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
biology
Pseudomonas Oxadiazole 1 2 4-Triazole L-Methionine Biological activity General Chemistry Organometallic complex Carbon-13 NMR biology.organism_classification medicine.disease_cause Ligands Medicinal chemistry lcsh:Chemistry chemistry.chemical_compound chemistry lcsh:QD1-999 Proton NMR medicine Diazole thiols Agar diffusion test Antibacterial activity Escherichia coli |
| Zdroj: | Journal of Saudi Chemical Society, Vol 24, Iss 12, Pp 1051-1059 (2020) |
| ISSN: | 1319-6103 |
| Popis: | Four novel heterocyclic1,3,4-oxadiazole, 1,2,4-triazole derivatives, namely: 5-[1-amino-3-(methylsulfanyl)propyl]-1,3,4-oxadiazole-2(3H)-thione (4), 4-amino-5-[1-amino-3-(methylsulfanyl)propyl]-4H-1,2,4-triazole-3-thiol (5), 1-amino-3-[1-amino-3-(methylsulfanyl)propyl]-1H-1,2,4-triazole-5-thiol (7), and 5-[1-amino-3-(methylsulfanyl)propyl]-1H-1,2,4-triazole-3-thiol (9) have been synthesized from l-methionine and characterized by different spectroscopic techniques (FT-IR, UV–Vis, 1H NMR, 13C NMR and MS). Complex formation with Hg++ and Fe+++ ions were formed from the four heterocyclic 4, 5, 7 and 9. The antimicrobial activities for synthetic intermediates and final four products were assisted using paper disk diffusion method against Gram-negative bacteria: Escherichia coli, Pseudomonas aeroginosae and Gram-positive bacteria: Staphylococus aureus 25923, Staphylococus aureus 43300 and showed variant activity against some of the microorganisms tested. |
| Databáze: | OpenAIRE |
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