Contrasting effects of IFN and IVIG in children with central and peripheral demyelination
| Autor: | Brian G. Weinshenker, M. Patterson, Nancy L. Kuntz, Moses Rodriguez, Istvan Pirko, B. M. Keegan |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Multiple Sclerosis medicine.medical_treatment Context (language use) Central nervous system disease Route of administration Autoimmune Diseases of the Nervous System hemic and lymphatic diseases medicine Demyelinating disease Humans Child Chemotherapy business.industry Multiple sclerosis Therapeutic effect Immunoglobulins Intravenous Polyradiculoneuropathy Interferon-beta medicine.disease Treatment Outcome Polyradiculoneuropathy Chronic Inflammatory Demyelinating Organ Specificity Child Preschool Immunology Female Neurology (clinical) business Interferon beta-1a |
| Zdroj: | Neurology. 60:1697-1699 |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/01.wnl.0000064163.94122.eb |
| Popis: | Reported are three children with MS who responded dramatically to interferon-beta (IFNbeta) therapy. While on immunomodulatory therapy, they developed chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) that responded to IV immunoglobulin (IVIG) administration. These cases emphasize two interesting observations: 1) IFNbeta treatment did not prevent development of CIDP; 2) CIDP in the context of MS responded to IVIG, even though IVIG had no therapeutic effect on the central demyelinating disease. |
| Databáze: | OpenAIRE |
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