Increased oxidative stress and inflammatory markers contrasting with the activation of the cholinergic anti-inflammatory pathway in patients with metabolic syndrome
| Autor: | Daniela Lopes dos Santos, Caroline Curry Martins, Vera Maria Morsch, Maria Rosa Chitolina Schetinger, Margarete Dulce Bagatini, Júlia Leão Batista Simões, Andréia Machado Cardoso, Jucimara Baldissarelli, Diéssica Padilha Dalenogare |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 030213 general clinical medicine medicine.medical_specialty Antioxidant medicine.medical_treatment Clinical Biochemistry Inflammation 030204 cardiovascular system & hematology medicine.disease_cause Thiobarbituric Acid Reactive Substances Antioxidants Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine TBARS Humans Cholinergic anti-inflammatory pathway Aged Metabolic Syndrome business.industry Patient Selection General Medicine Glutathione Middle Aged Prognosis Uric Acid Oxidative Stress Endocrinology C-Reactive Protein chemistry Acetylcholinesterase Uric acid Female Lipid Peroxidation medicine.symptom Inflammation Mediators business Oxidative stress Biomarkers Follow-Up Studies |
| Zdroj: | Clinical biochemistry. 89 |
| ISSN: | 1873-2933 |
| Popis: | Introduction Metabolic syndrome (MetS) is a disorder that is closely associated with risk factors that increase the chance of atherosclerosis and cardiovascular diseases. We demonstrate the presence of inflammation and oxidative stress in patients with MetS through levels of antioxidants and oxidative and inflammatory markers, in order to determine influential variables in therapy. Methods: In this study, lipid peroxidation, carbonylated protein content and enzymatic and non-enzymatic antioxidants were evaluated in samples obtained from 30 patients with MetS and 30 control patients. In addition, acetylcholinesterase (AChE) activity, C-reactive protein (CRP) and uric acid (UA) levels were determined to investigate the inflammatory process in patients with MetS. Results: Our results demonstrated an increase in the levels of oxidative markers, such as substances reactive to thiobarbituric acid (TBARS) and carbonyl protein. In addition, a decrease in the defense of non-enzymatic antioxidants, such as levels of vitamin C and glutathione (GSH) in patients with MetS. As for inflammatory markers, CRP and UA were increased in patients with MetS. Finally, activation of the cholinergic anti-inflammatory pathway was observed due to decreased AchE activity in patients with MetS. Conclusion The analyzes indicated oxidative stress, together with a reduction in the levels of antioxidant enzymes, corroborating the high consumption of these proteins. In addition, inflammation and activation of the cholinergic anti-inflammatory pathway was observed by the AChE analysis. Thus, the activation of this pathway can be studied as a possible route to a potential therapy. In addition, the markers AChE, CRP and UA may be used as a focus for the treatment of MetS. |
| Databáze: | OpenAIRE |
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