Detection of enterotoxigenic E. coli in hospitalised children with and without diarrhoea in Blantyre, Malawi
| Autor: | Nigel A. Cunliffe, Bagrey Ngwira, Eamonn Trainor, Miren Iturriza-Gomara |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Diarrhea
Male 0301 basic medicine Malawi Pediatrics medicine.medical_specialty 030106 microbiology 030231 tropical medicine medicine.disease_cause Gastro enteritis Enterotoxigenic E. coli Enterotoxins Feces 03 medical and health sciences fluids and secretions 0302 clinical medicine Rotavirus medicine Enterotoxigenic Escherichia coli Humans Escherichia coli Infections business.industry Infant Rotavirus vaccine Gastroenteritis Child Preschool Pediatrics Perinatology and Child Health Female business Child Hospitalized Co infection |
| Zdroj: | Paediatrics and International Child Health. 36:102-105 |
| ISSN: | 2046-9055 2046-9047 |
| DOI: | 10.1179/2046905515y.0000000014 |
| Popis: | Enterotoxigenic E. coli (ETEC) is an important cause of diarrhoea among children in developing countries. The burden of ETEC infection was investigated for the first time in children in Malawi.Faecal samples obtained from children 5 years of age hospitalised with diarrhoea in Blantyre, Malawi over a 10-year period (1997-2007) before introduction of the rotavirus vaccine were examined by PCR for ETEC heat-labile (LT) and heat-stable (STh and STp) enterotoxins. Children hospitalised without diarrhoea were enrolled over a 2-year period as a comparison group.ETEC was detected in 205 (10.6%) of 1941 children with diarrhoea. The most prevalent toxin type was STh (6·6%), followed by LT (2·1%) and STp (0·9%). ETEC infection was most prevalent in infants aged 6-11 months. Co-infection with rotavirus was common. ETEC was detected in 37 (7·3%) of 507 children without diarrhoea.The burden of ETEC infection in young Malawian children is substantial and should become a focus of diarrhoea prevention efforts in the post-rotavirus vaccine era. |
| Databáze: | OpenAIRE |
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