Autonomic neural signals in bone: Physiological implications for mandible and dental growth
| Autor: | Marta G Ladizesky, Rodolfo A. Cutrera, Veronica Boggio, Daniel P. Cardinali |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Sympathetic nervous system Superior cervical ganglion Bone density Mandibular Nerve Mandible General Biochemistry Genetics and Molecular Biology Bone remodeling Dental Physiological Phenomena stomatognathic system Incisor Osteoclast Internal medicine medicine Animals Humans Autonomic Pathways Sympathectomy General Pharmacology Toxicology and Pharmaceutics business.industry General Medicine Anatomy stomatognathic diseases Autonomic nervous system medicine.anatomical_structure Endocrinology Bone Remodeling business Tooth |
| Zdroj: | Life Sciences. 75:383-395 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/j.lfs.2003.11.031 |
| Popis: | Signals derived from the autonomic nervous system exert potent effects on osteoclast and osteoblast function. A ubiquitous sympathetic and sensory innervation of all periosteal surfaces exists and its disruption affects bone remodeling. Several neuropeptides, neurohormones and neurotransmitters and their receptors are detectable in bone. Bone mineral content decreased in sympathetically denervated mandibular bone. When a mechanical stress was superimposed on mandibular bone by cutting out the lower incisors, an increase in bone density ensued providing the sympathetic innervation was intact. A lower eruption rate of sympathetically denervated incisors at the impeded eruption side, and a higher eruption rate of denervated incisors at the unimpeded side were also observed. A normal sympathetic neural activity appears to be a pre-requisite for maintaining a minimal normal unimpeded incisor eruption and for keeping the unimpeded eruption to attain abnormally high velocities under conditions of stimulated incisor growth. These and other results suggest that the sympathetic nervous system plays an important role in mandibular bone metabolism. |
| Databáze: | OpenAIRE |
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