Perfusion CT of the brain: diagnostic approach for early detection of ischemic stroke
| Autor: | J F Spittler, L Heuser, D J Venderink, M Koenig, Ernst Klotz, B Luka |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Tomography Scanners X-Ray Computed Ischemia Contrast Media Perfusion scanning Brain Ischemia Central nervous system disease medicine Humans Radiology Nuclear Medicine and imaging Cysteine Stroke Aged Aged 80 and over Tomography Emission-Computed Single-Photon medicine.diagnostic_test Vascular disease business.industry Brain Magnetic resonance imaging Organotechnetium Compounds Middle Aged medicine.disease Cerebral blood flow Evaluation Studies as Topic Cerebrovascular Circulation Female Radiology Radiopharmaceuticals Tomography X-Ray Computed business Nuclear medicine Perfusion |
| Zdroj: | Radiology. 209:85-93 |
| ISSN: | 1527-1315 0033-8419 |
| DOI: | 10.1148/radiology.209.1.9769817 |
| Popis: | To determine the value of perfusion computed tomography (CT) in a clinical study of patients with stroke and compare the results with single photon emission CT (SPECT) findings.Perfusion CT was performed within 6 hours of symptom onset in 32 patients with possible stroke. Cerebral blood volume (CBV), cerebral blood flow (CBF), and time to peak contrast material enhancement were calculated on the basis of the CT results. Cerebral SPECT was also performed in a subgroup of 18 patients. Perfusion CT and SPECT findings were compared in a lesion-by-lesion analysis. Perfusion CT results were compared with follow-up CT and magnetic resonance imaging findings.Areas of reduced CBF were detected with the aid of perfusion CT in 25 of 28 patients with a proved infarct (sensitivity, 89%). The results of the CBF maps corresponded well to SPECT findings in 13 (81%) of 16 patients, but ischemia was located outside the scanning level in the other three patients and was therefore missed. Perfusion CT revealed various changes in CBF, CBV, and time to peak enhancement in ischemic territories.Perfusion CT not only allows early detection of cerebral ischemia but also yields valuable information about the extent of perfusion disturbances. |
| Databáze: | OpenAIRE |
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