68Ga-DOTATATE PET imaging in clinically non-functioning pituitary macroadenomas
| Autor: | Suat Simsek, Marcel P. M. Stokkel, Nienke R. Biermasz, Madeleine L. Drent, Charles B. L. M. Majoie, Eric Fliers, Tessel M. Boertien, Ronald Groote Veldman, Jan Booij, Alberto M. Pereira, Peter H. Bisschop |
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| Přispěvatelé: | Internal medicine, Radiology and nuclear medicine, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Amsterdam Gastroenterology Endocrinology Metabolism, ACS - Atherosclerosis & ischemic syndromes, Amsterdam Movement Sciences, Endocrinology, Graduate School, Radiology and Nuclear Medicine, Amsterdam Neuroscience - Brain Imaging, AMS - Ageing & Vitality, AMS - Musculoskeletal Health |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
lcsh:Medical physics. Medical radiology. Nuclear medicine
Adenoma PET/CT lcsh:R895-920 Short Communication Biophysics Scintigraphy Lanreotide 030218 nuclear medicine & medical imaging law.invention Ga-68-DOTATATE 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial In vivo law Computer Science (miscellaneous) Medicine Radiology Nuclear Medicine and imaging Somatostatin receptors PET-CT medicine.diagnostic_test MRI co-registration Somatostatin receptor business.industry 68Ga-DOTATATE medicine.disease PET chemistry Non-functioning pituitary adenoma Molecular Medicine Immunohistochemistry business Nuclear medicine 030217 neurology & neurosurgery CT |
| Zdroj: | european journal of hybrid imaging, 4(1):4. Springer European Journal of Hybrid Imaging, 4(1). SPRINGERNATURE Boertien, T M, Booij, J, Majoie, C B L M, Drent, M L, Pereira, A M, Biermasz, N R, Simsek, S, Veldman, R G, Stokkel, M P M, Bisschop, P H & Fliers, E 2020, ' 68Ga-DOTATATE PET imaging in clinically non-functioning pituitary macroadenomas ', european journal of hybrid imaging, vol. 4, no. 1, 4 . https://doi.org/10.1186/s41824-020-0073-3 European J Hybrid Imaging, 4:4 European Journal of Hybrid Imaging European Journal of Hybrid Imaging, Vol 4, Iss 1, Pp 1-7 (2020) |
| ISSN: | 2510-3636 |
| DOI: | 10.1186/s41824-020-0073-3 |
| Popis: | Purpose Clinically non-functioning pituitary macroadenomas (NFMA) have been reported to express somatostatin receptors (SSTR), but results are inconsistent across different studies. This may be related to limited sensitivity and specificity of techniques used to date, i.e. immunohistochemistry in surgical specimens and 111In-DTPA-octreotide scintigraphy in vivo. The aim of this study was to assess SSTR expression in NFMA in vivo using 68Ga-DOTATATE PET, which offers superior sensitivity and spatial resolution as compared with planar scintigraphy or SPECT. Methods Thirty-seven patients diagnosed with NFMA underwent 68Ga-DOTATATE PET/CT of the head in the framework of a randomised controlled trial assessing the effect of the somatostatin analogue lanreotide on NFMA size. Individual co-registered T1-weighted pituitary MRIs were used to assess 68Ga-DOTATATE uptake (SUVmean) in the adenoma. An SUVmean of > 2 was considered positive. Results 68Ga-DOTATATE uptake was positive in 34/37 patients (92%), with SUVmean of positive adenomas ranging from 2.1 to 12.4 (mean ± SD 5.8 ± 2.6). Conclusions This is the first report of 68Ga-DOTATATE PET performed in NFMA patients, demonstrating in vivo SSTR expression in the vast majority of cases. The high positivity rate when compared with results obtained with 111In-DTPA-octreotide scintigraphy probably reflects the superior sensitivity of PET imaging. Trial registration Netherlands Trial Register, NL5136, registered on 18 August 2015; EudraCT, 2015-001234-22, registered on 10 March 2015, https://eudract.ema.europa.eu/ |
| Databáze: | OpenAIRE |
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