Random mixtures of antimicrobial peptides inhibit bacteria associated with pasteurized bovine milk
| Autor: | Tal Stern Bauer, Zvi Hayouka |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microorganism 030106 microbiology Antimicrobial peptides Food spoilage Pasteurization Microbial Sensitivity Tests Bacillus subtilis medicine.disease_cause Biochemistry law.invention Structure-Activity Relationship 03 medical and health sciences fluids and secretions Structural Biology law Drug Discovery medicine Animals Food science Molecular Biology Pharmacology Dose-Response Relationship Drug biology Chemistry Organic Chemistry food and beverages General Medicine biology.organism_classification Antimicrobial Anti-Bacterial Agents Milk Psychrotrophic bacteria Biofilms Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization Molecular Medicine Cattle Peptides Bacteria |
| Zdroj: | Journal of Peptide Science. 24:e3088 |
| ISSN: | 1075-2617 |
| Popis: | The shelf life of pasteurized bovine milk is limited by microorganism activity as surviving bacteria continue to grow in the bovine milk, eventually causing milk spoilage. In the current study, we used matrix-assisted laser desorption ionization time of flight mass spectrometry to identify pasteurized bovine milk-associated mesophilic and psychrotrophic bacteria. We have recently designed random cationic peptide mixtures that possess strong antimicrobial and antibiofilm properties. These compounds are cheap and easy to synthesize and represent a new class of antimicrobial agents. Here, we show that the random peptide mixtures are able to efficiently eradicate the bacteria identified as associated with pasteurized bovine milk, and reduced significantly the growth of Bacillus subtilis in milk. We propose these antimicrobial peptides as potential candidates for integration in bioactive milk and food packaging to prevent bacterial growth and extend the shelf life of food. |
| Databáze: | OpenAIRE |
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