Self-Assembling Nonconjugated Poly(amide-imide) into Thermoresponsive Nanovesicles with Unexpected Red Fluorescence for Bioimaging
| Autor: | Yuping Xu, Meng-Zhen Wang, Donghui Pan, Xinyu Wang, Lizhen Wang, Junjie Yan, Min Yang, Runlin Yang |
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| Rok vydání: | 2019 |
| Předmět: |
Fluorophore
Polymers and Plastics Polymers Bioengineering 02 engineering and technology 010402 general chemistry Photochemistry Imides 01 natural sciences Fluorescence Biomaterials Hydrophobic effect chemistry.chemical_compound Bathochromic shift Amphiphile Materials Chemistry Imide Fluorescent Dyes Hydrogen bond Chemistry Hydrogen Bonding 021001 nanoscience & nanotechnology Amides 0104 chemical sciences PEGylation 0210 nano-technology Hydrophobic and Hydrophilic Interactions |
| Zdroj: | Biomacromolecules. 20(3) |
| ISSN: | 1526-4602 |
| Popis: | Nonconjugated red fluorescent polymers have been increasingly studied to improve the biocompatibility and penetration depth over conventional fluorescent materials. However, the accessibility of such polymers remains challenging due to the scarcity of nonconjugated fluorophores and lacking relevant mechanism of red-shifted fluorescence. Herein, we discovered that the combination of hydrogen bonding and π-π stacking interactions provides nonconjugated poly(amide-imide) with a large bathochromic shift (>100 nm) from blue-green fluorescence to red emission. The amphiphilic PEGylated poly(amide-imide) derived from in situ PEGylation self-assembled into nanovesicles in water, which isolated the aminosuccinimide fluorophore from the solvents and suppressed the hydrogen bonds formation between aminosuccinimide fluorophores and water. Therefore, the fluorescence of PEGylated poly(amide-imide) in water was soundly retained. Furthermore, the strong hydrogen bonding and hydrophobic interactions with water provided PEGylated poly(amide-imide) with a reversible thermoresponsiveness and presented a concentration-dependent behavior. Finally, accompanied by the excellent biostability and photostability, PEGylated poly(amide-imide) exhibited as a good candidate for cell imaging. |
| Databáze: | OpenAIRE |
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