Activation of Arc gene, a dendritic immediate early gene, by middle cerebral artery occlusion in rat brain
| Autor: | Hideyuki Kamii, Hisanori Kunizuka, Shigeki Mikawa, Kenji Izaki, Kazuo Mizoi, Takashi Yoshimoto, Shouichi Arai, Taku Sugawara, Akira Suzuki, Hiroyuki Kinouchi |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Middle Cerebral Artery Pathology medicine.medical_specialty Central nervous system Arterial Occlusive Diseases Nerve Tissue Proteins Striatum Hippocampal formation Biology Rats Sprague-Dawley medicine.artery medicine Animals RNA Messenger Genes Immediate-Early In Situ Hybridization Arc (protein) integumentary system General Neuroscience Dendrites Granule cell Rats Cytoskeletal Proteins medicine.anatomical_structure Ischemic Attack Transient Cerebral cortex Middle cerebral artery Autoradiography Dizocilpine Maleate DNA Probes Excitatory Amino Acid Antagonists Neuroscience Immediate early gene |
| Zdroj: | NeuroReport. 10:1717-1722 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-199906030-00017 |
| Popis: | The effect of middle cerebral artery (MCA) occlusion on the activity-regulated cytoskeleton-associated protein (Arc) mRNA expression has been investigated using in situ hybridization. It was induced in the extensive regions of cerebral cortex, medial striatum, and distant areas such as the ipsilateral lateral septal nucleus, bilateral hippocampal formation and contralateral amygdala following MCA occlusion. In the hippocampal formation, it was induced in the granule cell layer and the stratum pyramidale at 1 h and in the molecular layer and in the stratum oriens and stratum radiatum bilaterally at 4 h. MK-801 pretreatment strongly attenuated the induction of Arc mRNA. The present results suggest that Arc may play an important role in the neuronal plasticity through NMDA activation following focal cerebral ischemia. |
| Databáze: | OpenAIRE |
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