The mer receptor tyrosine kinase: expression and function suggest a role in innate immunity
| Autor: | Philip L. Cohen, Paul Gadue, Stacey Garrett, Edwards M. Behrens, Shunyou Gong, Paul L. Stein |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_treatment
Immunology Apoptosis C-Mer Tyrosine Kinase Receptor tyrosine kinase Interferon-gamma Mice Phagocytosis T-Lymphocyte Subsets Proto-Oncogene Proteins medicine Immunology and Allergy Animals IL-2 receptor Lymphocytes Mice Knockout Innate immune system biology c-Mer Tyrosine Kinase Macrophages Receptor Protein-Tyrosine Kinases Dendritic Cells Natural killer T cell Molecular biology Immunohistochemistry Immunity Innate Cell biology Killer Cells Natural Mice Inbred C57BL Cytokine biology.protein Interleukin 12 Interleukin-4 Antibody |
| Zdroj: | European journal of immunology. 33(8) |
| ISSN: | 0014-2980 |
| Popis: | The mer receptor tyrosine kinase mediates phagocytosis of apoptotic cells and modulates cytokine production; it is also required for prevention of systemic autoimmune disease. Using a mer-specific antibody, we have confirmed the presence of mer on macrophages and now report its expression on NK cells, NKT cells, and dendritic cells (DC). We found that DC do not require mer for ingestion of apoptotic cells, as DC from mer-deficient mice phagocytose apoptotic cells normally. Mer was observed in splenic sections on cells outside follicular areas, probably representing DC and macrophages. Mer apparently participates in NKT-cell antigen-induced signaling, as NKT cells from mer-deficient mice evinced much lower cytokine production after in vivo alpha-galactosylceramide stimulation; this defect was intrinsic to the mer-deficient NKT cells. Taken together, these studies show mer expression on cells of the innate immune system. Mer, through its binding of lipid antigens, may not only mediate ingestion of apoptotic cells, but also signal events in NK cells, NKT cells, and DC. |
| Databáze: | OpenAIRE |
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