Drug Use in Pregnancy
| Autor: | Jay M. Rao, Reginald Arulappu |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Drug
Pediatrics medicine.medical_specialty Drug-Related Side Effects and Adverse Reactions medicine.drug_class media_common.quotation_subject Fetal hydantoin syndrome Population Antibiotics Antitubercular Agents Fetal alcohol syndrome Antimalarials Fetus Pharmacotherapy Pregnancy medicine Humans Hypnotics and Sedatives Hypoglycemic Agents Abnormalities Multiple Pharmacology (medical) education Diethylstilbestrol Antihypertensive Agents media_common Gynecology Analgesics Psychotropic Drugs education.field_of_study business.industry Hydantoins Infant Newborn Abnormalities Drug-Induced medicine.disease Anti-Bacterial Agents Pregnancy Complications Fetal Alcohol Spectrum Disorders Histamine H1 Antagonists Antiemetics Female Warfarin business |
| Zdroj: | Drugs. 22:409-414 |
| ISSN: | 0012-6667 |
| DOI: | 10.2165/00003495-198122050-00004 |
| Popis: | The Obstetric Drug Information Service at the Queen Victoria Medical Center in Melbourne, Australia aims to provide relevant information relating to drug use in pregnancy. A preliminary study conducted by the Center revealed that 62.5% of pregnant women consumed drugs during their pregnancies (excluding iron and vitamins), with an average of 3 drugs per woman. Certain drugs are relatively safer than others, and the selection of the appropriate drug for a pregnant patient is very important to the future health and well-being of the child. At least 5% of all birth defects are drug induced. The drugs that produce fetal abnormalities are called "dysmorphogens" or "teratogens". General principles of drug use in pregnancy are outlined. These include the following: 1) no drug should be considered 100% safe to the developing fetus, including topical preparations; 2) a true indication must be present for the administration of any drug; 3) the potential benefits should always be weighed against the possible hazards of that drug to the mother and the fetus; and 4) the effect of a drug on the fetus may not necessarily be the same as the intended pharmacological effect on the mother. The following specific drug induced embryopathies are reviewed: fetal alcohol syndrome; Warfarin syndrome; fetal hydantoin syndrome; stilbestrol (diethylstilbestrol, DES) syndrome, VACTERL syndrome, and thalidomide embryopathy. Drugs which are safe for use in pregnancy are analgesics, hypnosedatives, antibiotics, antiemetics and antihistamines, psychotherapeutic drugs, antihypertensive drugs, antituberculous drugs, antimalarial drugs, antithyroid drugs, and antidiabetic drugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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