Assessment of membrane-organizing extension spike protein as a biomarker for periodontal disease by comparing its level in gingival crevicular fluid in individuals with and without chronic severe periodontitis – A pilot study
| Autor: | Rajesh Vyloppillil, Mohammed Shereef, Jayachandran Perayil, Biju Balakrishnan, Angel Fenol, Anjali Sreedharan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Periodontitis
medicine.medical_specialty business.industry Moesin periodontal disease Periodontology macromolecular substances Biomarker medicine.disease Severe periodontitis Group A Gastroenterology Group B lcsh:RK1-715 Scaling and root planing membrane-organizing extension spike protein lcsh:Dentistry Internal medicine Periodontics Medicine Biomarker (medicine) Original Article business |
| Zdroj: | Journal of Indian Society of Periodontology Journal of Indian Society of Periodontology, Vol 23, Iss 4, Pp 329-333 (2019) |
| ISSN: | 0975-1580 0972-124X |
| Popis: | Background: Membrane-organizing extension spike protein (Moesin) is a cytoskeletal protein expressed in the gingival crevicular fluid (GCF) which may play a role in the immune response in periodontal disease. The objective of this study was to evaluate whether Moesin can be used as a biomarker for periodontal disease. Materials and Methods: Thirty patients satisfying the required inclusion criteria were selected from those reporting to the out patient (OP) of the department of periodontics and divided into two groups: Group A – systemically healthy controls with no periodontitis and Group B – systemically healthy controls with chronic severe periodontitis. Periodontal parameters were recorded. GCF was collected, and Moesin levels in the two groups were assessed using enzyme-linked immunosorbent assay. Scaling and root planing (SRP) was done in Group B patients who were reviewed, and samples were collected again after 4 weeks and analyzed. Results: At baseline, the mean GCF Moesin level in Group A was 666.95 ± 471.872 pg/ml, while in Group B, it was found to be 27435.35 ± 14179.77 pg/ml, which showed a high statistically significant difference on comparison. The mean GCF Moesin level in patients with chronic severe periodontitis was 27435.35 ± 14179.77 pg/ml at baseline, and on review 1 month after SRP, it was found to have undergone a statistically significant reduction to 27161.23 ± 14161.57 pg/ml (P = 0.001). Conclusion: Within the limits of this study, it can be concluded that Moesin can serve as a potential biomarker for periodontal disease. |
| Databáze: | OpenAIRE |
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