A randomized comparison between rasburicase and allopurinol in children with lymphoma or leukemia at high risk for tumor lysis
| Autor: | Erin Morris, John S. Holcenberg, F. Leonard Johnson, Stanton Goldman, Raymond J. Hutchinson, Jerry Z. Finklestein, Susan G. Kreissman, Elizabeth Harvey, Conrad Tou, Mitchell S. Cairo |
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| Rok vydání: | 2001 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Lymphoma Urate Oxidase Allopurinol medicine.medical_treatment Immunology Kidney Biochemistry Gastroenterology chemistry.chemical_compound Allantoin Risk Factors Internal medicine medicine Rasburicase Humans Renal Insufficiency Hyperuricemia Child Chemotherapy Leukemia business.industry Infant nutritional and metabolic diseases Urate oxidase Drugs Investigational Cell Biology Hematology medicine.disease Recombinant Proteins Uric Acid Surgery Tumor lysis syndrome Kinetics Treatment Outcome chemistry Child Preschool Creatinine Uric acid Female Tumor Lysis Syndrome business medicine.drug |
| Zdroj: | Blood. 97:2998-3003 |
| ISSN: | 1528-0020 0006-4971 |
| Popis: | Standard therapy in the United States for malignancy-associated hyperuricemia consists of hydration, alkalinization, and allopurinol. Urate oxidase catalyzes the enzymatic oxidation of uric acid to a 5 times increased urine soluble product, allantoin. Rasburicase is a new recombinant form of urate oxidase available for clinical evaluation. This multicenter randomized trial compared allopurinol to rasburicase in pediatric patients with leukemia or lymphoma at high risk for tumor lysis. Patients received the assigned uric acid-lowering agent for 5 to 7 days during induction chemotherapy. The primary efficacy end point was to compare the area under the serial plasma uric acid concentration curves during the first 96 hours of therapy (AUC0-96). Fifty-two patients were randomized at 6 sites. In an intent-to-treat analysis, the mean uric acid AUC0-96 was 128 ± 70 mg/dL.hour for the rasburicase group and 329 ± 129 mg/dL.hour for the allopurinol group (P |
| Databáze: | OpenAIRE |
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