Approaches for encephalic drug delivery using nanomaterials: The current status
| Autor: | Paladugu Mourya, Brijesh Singh Rajput, Anoop, Githa Thomas, Linda Ilene Cutinho, Amala Maxwell |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Drug media_common.quotation_subject Nanoparticle Nanotechnology Blood–brain barrier Nanomaterials 03 medical and health sciences 0302 clinical medicine Drug Delivery Systems Central Nervous System Diseases medicine Animals Humans Metal nanoparticles media_common Chemistry General Neuroscience Bioavailability Nanostructures 030104 developmental biology medicine.anatomical_structure Nanomedicine Targeted drug delivery Blood-Brain Barrier Drug delivery 030217 neurology & neurosurgery |
| Zdroj: | Brain research bulletin. 155 |
| ISSN: | 1873-2747 |
| Popis: | Nanotechnology, the investigation of little structures, ranging from the size of 1 nm–100 nm presents a breakthrough in the field of targeted drug delivery. The microvasculature in the human brain along with the blood brain barrier (BBB) offers high resistance to the entry of therapeutics agents and other substances in to the brain. Nanoparticles have certain advantages as high permeability, reactivity, surface area and quantum properties and it also meets various medical challenges which may include poor bioavailability, difficulty in targeting, organ toxicity etc. The use of nanoparticles in pharmaceuticals has been inspired by various natural nanomaterials found in the body, which includes proteins, lipids etc. A brief explanation of different types of pharmaceutical approaches used in brain drug delivery is discussed here. Nanotechnology is used treatment of many illnesses which also include diseases related to the brain such as gliomas, epilepsy, migraine, cerebrovascular disease, Parkinson’s disease etc., Different type of nanoparticles are prepared, such as polymer-based nanoparticles, metallic nanoparticles, carbon-based nanoparticles, lipid-based nanoparticles, ceramic nanoparticles semiconductor nanoparticles and are studied for their usefulness in drug delivery. The primary function of nanoparticles is to deliver drug moiety to the desired targeted site by overcoming permeability issues. The shape, size and surface area nanoparticles help in increasing the bioavailability, drug retention and multiple drug delivery. Mechanisms of nanoparticles crossing BBB can be divided into passive and active transport, are briefly explained. |
| Databáze: | OpenAIRE |
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