Serum Neopterin, Retinol and Alpha-tocopherol in Patients with the Carcinoma of the Esophagus
| Autor: | Lenka Kujovská Krčmová, Eva Malirova, Karel Cwiertka, Petr Schneiderka, Bohuslav Melichar, Vlastislav Šrámek, Jan Cincibuch, Dagmar Solichová, Miloslava Kapustová, Hana Študentová, Jarmila Juránová, Kasparová M |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Urinary system Clinical Biochemistry Biochemistry esophageal carcinoma chemistry.chemical_compound alpha-tocopherol immune system diseases Internal medicine medicine Carcinoma Peripheral blood cell Esophagus Crystallography business.industry Retinol Neopterin Radioimmunoassay medicine.disease medicine.anatomical_structure Endocrinology neopterin chemistry QD901-999 Molecular Medicine alpha-Tocopherol business retinol |
| Zdroj: | ResearcherID Pteridines, Vol 20, Iss 1, Pp 49-53 (2009) |
| ISSN: | 2195-4720 0933-4807 |
| DOI: | 10.1515/pteridines.2009.20.1.49 |
| Popis: | Increased serum or urinary concentrations of neopterin have been described in patients with tumors of different primary locations, but reports on neopterin in patients with esophageal carcinoma are scanty. We have studied serum neopterin, retinol and alpha-tocopherol in 45 patients with carcinoma of the esophagus or gastroesophageal junction. Serum neopterin was determined using radioimmunoassay. Retinol and alpha-tocopherol were determined by high-performance liquid chromatography. Serum neopterin in patients with carcinoma of the esophagus was significantly increased while retinol and alpha-tocopherol were significantly decreased compared to controls. No correlation of neopterin with hemoglobin or peripheral blood cell counts was observed. During chemoradiation, neopterin increased significantly, while retinol and alpha-tocopherol did not change. In conclusion, the present study demonstrates increased serum neopterin and decreased retinol and alpha-tocopherol concentrations in patients with esophageal carcinoma. Chemoradiation induced a further increase of serum neopterin concentrations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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