Lactate dehydrogenase isoenzyme patterns in the tumour-bearing colon
| Autor: | E. Langvad |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Electrophoresis
Cancer Research medicine.medical_specialty L-Lactate Dehydrogenase Metabolic change Biology Molecular biology Lactate dehydrogenase isoenzymes Isoenzymes Isoenzyme pattern chemistry.chemical_compound Endocrinology Oncology chemistry Lactate dehydrogenase Internal medicine Colonic Neoplasms medicine Humans |
| Zdroj: | International Journal of Cancer. 3:17-29 |
| ISSN: | 1097-0215 0020-7136 |
| DOI: | 10.1002/ijc.2910030104 |
| Popis: | The lactate dehydrogenase (LDH) isoenzyme pattern of the tumour-bearing colon has been studied in homogenates by disc-electrophoretic separation. The preponderance of M-LDH in malignant tissue has been confirmed. It has been shown that the isoenzyme pattern may be altered in the absence of morphological changes. Thus, the metabolic change is not specifically dependent on the existence of tumorous parenchymatous changes as currently recognized by light microscopy. It is suggested that the tumour develops within a tissue where metabolic modifications may precede the stage of morphological malignancy. It appears, therefore, that the alteration of the enzyme pattern might be symptomatic of an established, but very early, neoplastic condition, the microscopic recognition malignancy being a later development. Systemes D'isoenzymes de la Deshydrogenase Lactique Dans le Cǒlon Porteur D'UNE Tumeur On a etudie le systeme d'isoenzymes de la deshydrogenase lactique (LDH) du cǒlon atteint D'UNE tumeur; cette etude a ete faite sur des homogenats par separation a l'aide D'UNE electrophorese sur disque. La preponderance de la M-LDH dans le tissu malin a ete confirmee. On a montre que le systeme isoenzymatique peut etre modifie en l'absence de changement morphologique. Par consequent, la modification metabolique ne depend pas specifiquement de l'existence des modifications tumorales du parenchyme ordinairement reconnues par microscopie optique. l'auteur estime que la tumeur se developpe dans un tissu ou des modifications metaboliques precedent peut-ětre les modifications morphologiques observables. Il semble done que l'alteration du systeme enzymatique pourrait etre symptomatique d'un etat neoplastique deja installe mais encore tres recent, la constatation du caractere malin du tissu au microscope n'intervenant que plus tardivement. |
| Databáze: | OpenAIRE |
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