Response of knee cartilage T1rho and T2 relaxation times to in vivo mechanical loading in individuals with and without knee osteoarthritis
| Autor: | Richard B. Souza, Sharmila Majumdar, Deepak Kumar, Thomas M. Link, Nathaniel E. Calixto, Karupppasamy Subburaj, J. K. Singh, J. Schooler, Xiaojuan Li |
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| Rok vydání: | 2014 |
| Předmět: |
Cartilage
Articular Male Knee Joint Biomedical Engineering Osteoarthritis medicine.disease_cause Article Weight-bearing Weight-Bearing Rheumatology medicine Image Processing Computer-Assisted Humans Femur Orthopedics and Sports Medicine Tibia medicine.diagnostic_test Chemistry Cartilage Relaxation (NMR) Magnetic resonance imaging Anatomy Middle Aged Osteoarthritis Knee medicine.disease Magnetic Resonance Imaging Acute loading medicine.anatomical_structure Case-Control Studies Female Biomedical engineering |
| Zdroj: | BASE-Bielefeld Academic Search Engine |
| ISSN: | 1063-4584 |
| DOI: | 10.1016/j.joca.2014.04.017 |
| Popis: | summary Objective: The objective of this study was to evaluate the effects of mechanical loading on knee articular cartilage T1r and T2 relaxation times in patients with and without osteoarthritis (OA). Design: Magnetic resonance (MR) images were acquired from 137 subjects with and without knee OA under two conditions: unloaded and loaded at 50% body weight. Three sequences were acquired: a high-resolution 3D-CUBE, a T1r relaxation time, and a T2 relaxation time sequences. Cartilage regions of interest included: medial and lateral femur (MF, LF); medial and lateral tibia (MT, LT), laminar analysis (superficial and deep layers), and subcompartments. Changes in relaxation times in response to loading were evaluated. Results: In response to loading, we observed significant reductions in T1r relaxation times in the MT and LT. In both the MF and LF, loading resulted in significant decreases in the superficial layer and significant increases in the deep layer of the cartilage for T1r and T2. All subcompartments of the MT and LT showed significant reduction in T1r relaxation times. Reductions were larger for subjects with OA (range: 13e19% change) when compared to healthy controls (range: 3e13% change). Conclusions: Loading of the cartilage resulted in significant changes in relaxation times in the femur and tibia, with novel findings regarding laminar and subcompartmental variations. In general, changes in relaxation times with loading were larger in the OA group suggesting that the collageneproteoglycan matrix of subjects with OA is less capable of retaining water, and may reflect a reduced ability to dissipate loads. |
| Databáze: | OpenAIRE |
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