Three-Dimensional Optoacoustic and Laser-Induced Ultrasound Tomography System for Preclinical Research in Mice: Design and Phantom Validation
| Autor: | Sergey A. Ermilov, Richard Su, Alexander A. Oraevsky, Fatima Anis, Vyacheslav Nadvoretskiy, André Conjusteau, Mark A. Anastasio |
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| Rok vydání: | 2015 |
| Předmět: |
Materials science
02 engineering and technology 01 natural sciences Imaging phantom law.invention 010309 optics Photoacoustic Techniques Preclinical research Mice Imaging Three-Dimensional law Small animal 0103 physical sciences Animals Radiology Nuclear Medicine and imaging Whole Body Imaging Tomography Ultrasonography Radiological and Ultrasound Technology Phantoms Imaging Lasers Reproducibility of Results 021001 nanoscience & nanotechnology Laser Ultrasound Tomography 0210 nano-technology 3d angiography Preclinical imaging Biomedical engineering |
| Zdroj: | Ultrasonic imaging. 38(1) |
| ISSN: | 1096-0910 |
| Popis: | In this work, we introduce a novel three-dimensional imaging system for in vivo high-resolution anatomical and functional whole-body visualization of small animal models developed for preclinical and other type of biomedical research. The system (LOUIS-3DM) combines a multiwavelength optoacoustic tomography (OAT) and laser-induced ultrasound tomography (LUT) to obtain coregistered maps of tissue optical absorption and speed of sound, displayed within the skin outline of the studied animal. The most promising applications of the LOUIS-3DM include 3D angiography, cancer research, and longitudinal studies of biological distributions of optoacoustic contrast agents. |
| Databáze: | OpenAIRE |
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