A metabolome-wide association study in the general population reveals decreased levels of serum laurylcarnitine in people with depression
| Autor: | Jan Krumsiek, Helena U. Zacharias, Henry Völzke, Seryan Atasoy, Gabi Kastenmüller, Nele Friedrich, Maik Pietzner, Karl-Heinz Ladwig, Christian Gieger, Johannes Hertel, Sonja Kunze, Karoline Lukaschek, Hamimatunnisa Johar, Hans J. Grabe, Matthias Nauck |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Population Article Molecular biology Psychology Body Mass Index Cohort Studies Cellular and Molecular Neuroscience Metabolomics Internal medicine medicine Metabolome Humans ddc:610 drug therapy [Depression] education Molecular Biology Suicidal ideation Depression (differential diagnoses) Genetic association education.field_of_study business.industry Depression ddc Psychiatry and Mental health Study of Health in Pomerania Cohort medicine.symptom business |
| Zdroj: | Mol. Psychiatry 26, 7372–7383 (2021) Molecular psychiatry 26(12), 7372-7383 (2021). doi:10.1038/s41380-021-01176-0 |
| ISSN: | 1476-5578 |
| DOI: | 10.1038/s41380-021-01176-0 |
| Popis: | Depression constitutes a leading cause of disability worldwide. Despite extensive research on its interaction with psychobiological factors, associated pathways are far from being elucidated. Metabolomics, assessing the final products of complex biochemical reactions, has emerged as a valuable tool for exploring molecular pathways. We conducted a metabolome-wide association analysis to investigate the link between the serum metabolome and depressed mood (DM) in 1411 participants of the KORA (Cooperative Health Research in the Augsburg Region) F4 study (discovery cohort). Serum metabolomics data comprised 353 unique metabolites measured by Metabolon. We identified 72 (5.1%) KORA participants with DM. Linear regression tests were conducted modeling each metabolite value by DM status, adjusted for age, sex, body-mass index, antihypertensive, cardiovascular, antidiabetic, and thyroid gland hormone drugs, corticoids and antidepressants. Sensitivity analyses were performed in subcohorts stratified for sex, suicidal ideation, and use of antidepressants. We replicated our results in an independent sample of 968 participants of the SHIP-Trend (Study of Health in Pomerania) study including 52 (5.4%) individuals with DM (replication cohort). We found significantly lower laurylcarnitine levels in KORA F4 participants with DM after multiple testing correction according to Benjamini/Hochberg. This finding was replicated in the independent SHIP-Trend study. Laurylcarnitine remained significantly associated (p value |
| Databáze: | OpenAIRE |
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