Enhanced displacement of [3H]imipramine, but not [3H]paroxetine binding by plasma from depressed patients
| Autor: | Kevin M. Lawrence, Jan Falkowski, Roger W. Horton, Robin R. Jacobson, Sandra Lowther |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Blood Platelets Male Imipramine Immunodiffusion medicine.medical_specialty Platelet Membrane Glycoproteins Tritium Binding Competitive Radioligand Assay Internal medicine Blood plasma medicine Humans Platelet chemistry.chemical_classification Depressive Disorder Chemistry Cell Membrane Blood Proteins Orosomucoid Middle Aged Endogenous modulator Paroxetine In vitro Psychiatry and Mental health Clinical Psychology Endocrinology Receptors Serotonin Antidepressant Female Glycoprotein medicine.drug |
| Zdroj: | Journal of Affective Disorders. 46:127-134 |
| ISSN: | 0165-0327 |
| DOI: | 10.1016/s0165-0327(97)00095-5 |
| Popis: | Plasma from healthy subjects inhibited the binding of [ 3 H ]imipramine competitively and [ 3 H ]paroxetine non-competitively to platelet membranes in a volume-dependent manner. Plasma from 40 depressed patients was more effective at inhibiting [ 3 H ]imipramine, but not [ 3 H ]paroxetine, binding compared to plasma from matched controls. This difference was not related to recent antidepressant treatment. The results suggest that the concentration of an endogenous modulator of [ 3 H ]imipramine binding is increased in depressive illness. The concentration of α 1 -acid glycoprotein, a proposed endogenous modulator of [ 3 H ]imipramine binding, did not differ between depressed patients and controls. Our results suggest that factors other than α 1 -acid glycoprotein may modulate [ 3 H ]imipramine binding. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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