Modulation of calcium signalling by mitochondria
| Autor: | Alexei V. Tepikin, Michael Chvanov, Stephanie L. Barrow, Ole H. Petersen, Svetlana Voronina, Ciara M. Walsh |
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| Rok vydání: | 2009 |
| Předmět: |
SERCA
Biophysics IP3 receptor Biology Mitochondrion Biochemistry Adenosine Triphosphate Animals Humans Inositol 1 4 5-Trisphosphate Receptors Calcium Signaling Uniporter Calcium signaling Calcium signalling ROS Ryanodine Receptor Calcium Release Channel Cell Biology Inositol trisphosphate receptor Mitochondria Cell biology ATP Cytosol Ryanodine receptor Store-operated Ca2+ entry Plasma membrane Ca2+ ATPase NAD+ kinase |
| Zdroj: | Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1787:1374-1382 |
| ISSN: | 0005-2728 |
| Popis: | In this review we will attempt to summarise the complex and sometimes contradictory effects that mitochondria have on different forms of calcium signalling. Mitochondria can influence Ca(2+) signalling indirectly by changing the concentration of ATP, NAD(P)H, pyruvate and reactive oxygen species - which in turn modulate components of the Ca(2+) signalling machinery i.e. buffering, release from internal stores, influx from the extracellular solution, uptake into cellular organelles and extrusion by plasma membrane Ca(2+) pumps. Mitochondria can directly influence the calcium concentration in the cytosol of the cell by importing Ca(2+) via the mitochondrial Ca(2+) uniporter or transporting Ca(2+) from the interior of the organelle into the cytosol by means of Na+/Ca(2+) or H+/Ca(2+) exchangers. Considerable progress in understanding the relationship between Ca(2+) signalling cascades and mitochondrial physiology has been accumulated over the last few years due to the development of more advanced optical techniques and electrophysiological approaches. |
| Databáze: | OpenAIRE |
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