Impulse oscillometry and nitrogen washout test in the assessment of small airway dysfunction in asthma: Correlation with quantitative computed tomography
| Autor: | Martina Sbarra, Carola Condoluci, Giuseppe Macis, Chiara Contu, Giulia Angeletti, Leonello Fuso, Emanuele Giovanni Conte, Paolo Montuschi |
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| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty Settore BIO/14 - FARMACOLOGIA Nitrogen washout test Air trapping 03 medical and health sciences 0302 clinical medicine Internal medicine Oscillometry Immunology and Allergy Medicine Humans 030212 general & internal medicine Plethysmography Impedance Quantitative computed tomography air trapping impulse oscillometry Lung Asthma medicine.diagnostic_test business.industry Airway Resistance Single breath respiratory system Middle Aged medicine.disease Disease control respiratory tract diseases Respiratory Function Tests Impulse Oscillometry 030228 respiratory system Pediatrics Perinatology and Child Health Cardiology Airway Remodeling Female medicine.symptom business Airway Tomography X-Ray Computed |
| Zdroj: | The Journal of asthma : official journal of the Association for the Care of Asthma. 56(3) |
| ISSN: | 1532-4303 |
| Popis: | Small airway dysfunction (SAD) and airway remodeling influence the disease control and progression in asthma. We investigated whether impulse oscillometry (IOS) and single breath nitrogen washout (SBNLung function tests were performed before and after bronchodilator. The MDCT lung scans were acquired at full inspiration and expiration using a portable spirometer to control the respiratory manoeuvres. Symptom control was assessed using the Asthma Control Test (ACT) questionnaire.Twenty six patients were enrolled. The bronchial lumen area (LA) measured with MDCT lung scan, correlated inversely with airway resistance (Raw, p0.001) and with total and large airway oscillometric resistance (R5, p = 0.002 and R20, p = 0.006, respectively). However these two last correlations became non-significant after Bonferroni correction for multiple comparisons. The radiological quantification of air trapping correlated with Raw (p0.001), residual volume (RV, p0.001), and the slope of phase III of SBNPlethysmographic method remains the main tool to investigate SAD and airway remodeling in asthmatic patients. The integration with the SBN |
| Databáze: | OpenAIRE |
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