MicroRNAs and Their Roles in Breast Cancer Bone Metastasis
| Autor: | Manoj K. Valluru, Philippe Clézardin, Margherita Puppo |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Endocrinology Diabetes and Metabolism Cancer-induced Musculoskeletal Diseases (C Lynch and J Sterling Section Editors) Bone Neoplasms Breast Neoplasms Disease 03 medical and health sciences Breast cancer 0302 clinical medicine miRNA therapy microRNA Gene expression Biomarkers Tumor Tumor Microenvironment Humans Medicine Molecular Targeted Therapy Neoplasm Metastasis Predictive biomarker business.industry Advanced stage Cancer Bone metastasis medicine.disease MicroRNAs 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Female business Biomarkers |
| Zdroj: | Current Osteoporosis Reports |
| ISSN: | 1544-2241 1544-1873 |
| DOI: | 10.1007/s11914-021-00677-9 |
| Popis: | Bone metastasis occurs in advanced stages of breast cancer, worsening the quality of life and increasing the mortality of patients. Current treatments for bone metastasis are only palliative, and efficient therapeutic targets need to be still identified. MicroRNAs (miRNAs) are a large class of small non-coding RNAs that regulate gene expression within cells. Interestingly, the expression of certain miRNAs has been associated with several stages of bone metastasis progression, highlighting the importance of these small RNAs during the course of the metastatic disease. In this review, we aim to summarise the most recent findings on miRNAs and their mRNA targets in driving breast cancer bone metastasis. Furthermore, we discuss the possibility to use miRNAs as direct therapeutic targets or as advanced therapies for breast cancer bone metastasis, as well as their potential as predictive biomarkers of bone metastasis for an early diagnosis and a better tailoring of therapies for cancer patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink