ALUMINIUM RETENTION AND TOXICITY IN CHRONIC RENAL FAILURE
| Autor: | H. Thurston, J.D. Swales, G.R. Gilmore |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
inorganic chemicals
medicine.medical_specialty chemistry.chemical_element urologic and male genital diseases complex mixtures Bone and Bones Phosphates chemistry.chemical_compound Aluminium Internal medicine medicine Animals Humans Growth Disorders Aluminium hydroxide Rachitic bone changes General Medicine respiratory system Phosphate Rats respiratory tract diseases Endocrinology chemistry Toxicity Aluminum - blood Kidney Failure Chronic Chronic renal failure Aluminum |
| Zdroj: | The Lancet. 299:881-883 |
| ISSN: | 0140-6736 |
| DOI: | 10.1016/s0140-6736(72)90743-x |
| Popis: | Aluminium hydroxide is extensively used to correct the hyperphosphataemia of chronic renal failure, and it has been suggested that toxic amounts of aluminium are absorbed from this preparation. This hypothesis has been examined by administering aluminium hydroxide to normal growing rats and rats with chronic renal failure. Renal failure increased the deposition of aluminium in bone. Aluminium hydroxide impaired the growthrate of normal rats and produced rachitic bone changes, but this effect could be corrected by phosphate supplements. No impairment of growth was produced by aluminium hydroxide in hyperphosphataemic uraemic rats and no other pathological abnormalities could be demonstrated. Patients with chronic renal failure treated with aluminium hydroxide for prolonged periods showed similar bony levels of aluminium to the rats. The present work, whilst indicating that small quantities of aluminium are deposited in bone in chronic renal failure, indicates that aluminium hydroxide is non-toxic if hypophosphataemia is avoided. |
| Databáze: | OpenAIRE |
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