Fully automatic input function determination program for simple noninvasive 123 I-IMP microsphere cerebral blood flow quantification method

Autor: Asato Ofuji, Hiroaki Mimura, Yoshikazu Uchiyama, Teruki Sone, Shigeki Ito, Akihiro Takaki, Kosuke Yamashita, Shintaro Okumiya
Rok vydání: 2016
Předmět:
Male
Computer science
Biophysics
General Physics and Astronomy
Pulmonary Artery
Single-photon emission computed tomography
Pattern Recognition
Automated
030218 nuclear medicine & medical imaging
Iodine Radioisotopes
Automation
03 medical and health sciences
0302 clinical medicine
Inosine Monophosphate
Region of interest
Image Processing
Computer-Assisted
medicine
Humans
Radiology
Nuclear Medicine and imaging
Lung
Throughput (business)
Aged
Tomography
Emission-Computed
Single-Photon
Reproducibility
medicine.diagnostic_test
Angiography
Process (computing)
Reproducibility of Results
General Medicine
Repeatability
Middle Aged
Microspheres
Cerebral blood flow
Area Under Curve
Cerebrovascular Circulation
030220 oncology & carcinogenesis
Fully automatic
Regression Analysis
Female
Radiopharmaceuticals
Biomedical engineering
Zdroj: Physica Medica. 32:1180-1185
ISSN: 1120-1797
Popis: We recently developed a simple noninvasive (123)I-IMP microsphere (SIMS) method using chest dynamic planar images and brain single photon emission computed tomography. The SIMS method is an automatic analysis method, except for the process of setting the region of interest (ROI) of the input function. If a fully automatic ROI setting algorithm can be developed to determine the input function for the SIMS method, repeatability and reproducibility of the analysis of regional cerebral blood flow (rCBF) of the SIMS method can be guaranteed. The purpose of this study is to develop a fully automatic input function determination program for the SIMS method and to confirm the clinical usefulness of this program. The automatic input function determination program consists of two ROI setting programs for the PA and lung regions, and it is developed using the image phase analysis of a chest RI angiogram. To confirm the clinical usefulness of this program, the rCBF in 34 patients measured using the automatic method were compared with the values obtained through the manual setting method. Input functions by the automatic and manual methods were approximately equal. A good correlation was observed between the rCBF values obtained by the automatic method and those obtained by the manual setting method (r=0.96, p
Databáze: OpenAIRE
Externí odkaz: