The Intracranial Aneurysm Susceptibility Genes HSPG2 and CSPG2 Are Not Associated With Abdominal Aortic Aneurysm
| Autor: | Eric L.G. Verhoeven, Bart P. Boll, Jean-Paul P. M. de Vries, Annette F. Baas, Ruben van 't Slot, Jan D. Blankensteijn, Jelena Medic, Ynte M. Ruigrok, Cisca Wijmenga, Marc R.H.M. van Sambeek, Diederick E. Grobbee |
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| Přispěvatelé: | Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Surgery, ICaR - Ischemia and repair |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
Pathology medicine.medical_specialty Population CSPG2 Single-nucleotide polymorphism Bioinformatics association study HSPG2 Polymorphism Single Nucleotide CHROMOSOME 19Q13.3 FAMILIES DISEASE Aortic aneurysm Aneurysm Versicans abdominal aortic aneurysm single nucleotide polymorphism medicine LINKAGE LOCUS SNP Humans Genetic Predisposition to Disease HETEROGENEITY education Genotyping Genetic Association Studies SUBARACHNOID HEMORRHAGE METAANALYSIS Aged Aged 80 and over education.field_of_study Extracellular Matrix Proteins business.industry Haplotype Middle Aged medicine.disease intracranial aneurysm Abdominal aortic aneurysm cardiovascular system RISK-FACTORS Female Cardiology and Cardiovascular Medicine business Heparan Sulfate Proteoglycans Aortic Aneurysm Abdominal |
| Zdroj: | Angiology, 61(3), 238-242. SAGE Publications Inc. Baas, A F, Medic, J, van't Slot, R, Vries, J P P, van Sambeek, M R H M, Verhoeven, E L G, Boll, B P, Grobbee, D E, Wijmenga, C, Blankensteijn, J D & Ruigrok, Y M 2010, ' The Intracranial Aneurysm Susceptibility Genes HSPG2 and CSPG2 Are Not Associated With Abdominal Aortic Aneurysm ', Angiology, vol. 61, no. 3, pp. 238-242 . https://doi.org/10.1177/0003319709354751 |
| ISSN: | 0003-3197 |
| DOI: | 10.1177/0003319709354751 |
| Popis: | Background: A genetic variant on chromosome 9p21 associates with abdominal aortic aneurysm (AAA) and intracranial aneurysm (IA), indicating that despite the differences in pathology there are shared genetic risk factors. We investigated whether the IA susceptibility genes heparan sulfate proteoglycan 2 (HSPG2) and chondroitin sulfate proteoglycan 2 (CSPG2) associate with AAA as well. Methods: Using tag single nucleotide polymorphisms (SNPs), all common variants were analyzed in a Dutch AAA case-control population in a 2-stage genotyping approach. In stage 1, 12 tag SNPs in HSPG2 and 22 tag SNPs in CSPG2 were genotyped in 376 patients and 648 controls. Genotyping of significantly associated SNPs was replicated in a second independent cohort of 360 cases and 376 controls. Results: In stage 1, no HSPG2 SNPs and 1 CSPG2 SNP associated with AAA (rs2652106, P = .019). Association of this SNP was not replicated (P = .342). Conclusions: Our findings demonstrate that, in contrast to IA, HSPG2 and CSPG2 do not associate with AAA. |
| Databáze: | OpenAIRE |
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