Mean arterial pressure targeted fluid resuscitation may lead to fluid overload: A bleeding-resuscitation animal experiment

Autor:	Wolfgang Huber, N. Öveges, Gábor Lebák, Ildikó László, Dániel Érces, Krisztián Tánczos, Márton Németh, Bianca-Andreea Tudor-Drobjewski, József Kaszaki, László Rudas, Zsolt Molnár
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Male Resuscitation Critical Care and Emergency Medicine Swine Physiology medicine.medical_treatment Cardiac index lcsh:Medicine Blood Pressure Pathology and Laboratory Medicine Vascular Medicine 0302 clinical medicine Medicine and Health Sciences lcsh:Science Multidisciplinary Stroke volume Hematology Pulse pressure Body Fluids Stroke Chemistry Blood Neurology Shock (circulatory) Physical Sciences Cardiology Female medicine.symptom Anatomy Research Article Chemical Elements Biotechnology medicine.medical_specialty Mean arterial pressure Catheters Cerebrovascular Diseases Hemorrhage Shock Hemorrhagic 03 medical and health sciences Signs and Symptoms Diagnostic Medicine Internal medicine medicine Animals business.industry lcsh:R Hemodynamics Biology and Life Sciences 030208 emergency & critical care medicine Crystalloid Solutions Oxygen Blood pressure 030228 respiratory system Medical Devices and Equipment lcsh:Q Isotonic Solutions business Fluid replacement
Zdroj:	PLoS ONE, Vol 13, Iss 6, p e0196188 (2018) PLoS ONE
ISSN:	1932-6203
Popis:	INTRODUCTION Fluid resuscitation is the cornerstone of treatment in hemorrhagic shock. Despite increasing doubts, several guidelines recommend to maintain mean arterial pressure (MAP) >65 mmHg as the most frequent indication of fluid therapy. Our aim was to investigate the effects of a MAP-guided management in a bleeding-resuscitation animal experiment. MATERIALS AND METHODS After anesthesia and instrumentation (tbsl) animals were bled till the initial stroke volume index dropped by 50% (t0). Fluid replacement was performed in 4 equivalent steps (t1-4) with balanced crystalloid solution to reach the baseline values of MAP. Invasive hemodynamic measurements and blood gas analyses were performed after each step. RESULTS Mean arterial pressure dropped from tbsl to t0 (114±11 vs 76.9±16.9 mmHg, p
Databáze:	OpenAIRE
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