Cystine-knot peptides: emerging tools for cancer imaging and therapy
| Autor: | Nicolas V. Currier, Jamie M. Bergen, Shelley Erin Ackerman, Jennifer R. Cochran |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Tumor targeting
Antineoplastic Agents Cyclotides Cancer imaging Computational biology Pharmacology Biology Protein Engineering Biochemistry Irritable Bowel Syndrome Neoplasms Biomarkers Tumor Animals Humans Molecular Biology chemistry.chemical_classification Drug discovery Cystine knot Protein engineering Cystine-Knot Miniproteins Amino acid Molecular Imaging chemistry Molecular imaging Chronic Pain Radiopharmaceuticals human activities |
| Zdroj: | Expert review of proteomics. 11(5) |
| ISSN: | 1744-8387 |
| Popis: | Cystine-knot miniproteins, also known as knottins, constitute a large family of structurally related peptides with diverse amino acid sequences and biological functions. Knottins have emerged as attractive candidates for drug development as they potentially fill a niche between small molecules and protein biologics, offering drug-like properties and the ability to bind to clinical targets with high affinity and selectivity. Due to their extremely high stability and unique structural features, knottins also demonstrate promise in addressing challenging drug development goals, including the potential for oral delivery and the ability to access intracellular drug targets. Several naturally-occurring knottins have recently received approval for treating chronic pain and irritable bowel syndrome, while others are under development for tumor imaging applications. To expand beyond nature's repertoire, rational and combinatorial protein engineering methods are generating tumor-targeting knottins for use as cancer diagnostics and therapeutics. |
| Databáze: | OpenAIRE |
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