| Autor: |
Juan A. Rincón, Caroline Rouget-Virbel, Javier Agejas, Mario Barberis, Oscar de Frutos, Tomer M. Faraggi, Carlos Mateos, Susana García-Cerrada, David W. C. MacMillan |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Org Process Res Dev |
| Popis: |
We describe herein a two-step process for the conversion of serine to a wide array of optically pure unnatural amino acids. This method utilizes a photocatalytic cross-electrophile coupling between a bromoalkyl intermediate and a diverse set of aryl halides to produce artificial analogues of phenylalanine, tryptophan, and histidine. The reaction is tolerant of a broad range of functionalities and can be leveraged toward the scalable synthesis of valuable pharmaceutical scaffolds via flow technology. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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