Effect of the Somatostatin Analogue Lanreotide on Meal-Stimulated Portal Blood Flow in Patients with Liver Cirrhosis
| Autor: | Finn Larsen, Robert Sutton, Michael J. P. Arthur, Cornel C. Sieber, Daniel Grandt, Peter Schiedermaier, Phillip Harrison, Jürgen Drewe |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Cirrhosis Lanreotide Peptides Cyclic Gastroenterology chemistry.chemical_compound Double-Blind Method Gastrointestinal Agents Internal medicine Hypertension Portal Humans Medicine Gastrointestinal agent business.industry Ultrasonography Doppler Blood flow Middle Aged medicine.disease Portal System Somatostatin Postprandial Endocrinology Blood pressure chemistry Food Portal hypertension Female business |
| Zdroj: | Digestion. 65:56-60 |
| ISSN: | 1421-9867 0012-2823 |
| DOI: | 10.1159/000051932 |
| Popis: | Background: Lanreotide, a new long-acting somatostatin analogue, has been shown to inhibit the meal-stimulated increase of splanchnic blood flow in healthy volunteers. To date, similar data in patients with liver cirrhosis have not been available. We have examined the effect of lanreotide compared with placebo on meal-stimulated portal blood flow in patients with liver cirrhosis using Doppler ultrasound. Methods: 20 cirrhotic patients (placebo n = 12, lanreotide n = 8) with proven portal hypertension were studied after an overnight fast. Lanreotide, at a dose of 100 µg/h, was infused intravenously over 7 h after a 1-hour basal period. In parallel to the intravenous infusion, a liquid test meal (Ensure plusTM, 1.5 kcal/min) was perfused for 7 h through an intraduodenal tube at a rate of 3 ml/min. Blood pressure, heart rate and portal vein blood flow (PVF, ml/min, Doppler technique) were determined at regular intervals. Results: Baseline PVF amounted to 725 ± 182 ml/min in the placebo and to 917 ± 252 ml/min in the lanreotide group (n.s.). The meal-stimulated increase in PVF was blunted by lanreotide (AUC, %·min): 62,709.6 ± 6,817 (placebo) vs. 45,237 ± 2,507 (lanreotide), p < 0.05. Lanreotide also blunted the postprandial increase in heart rate for the first 2 h of meal perfusion. Conclusions: Because of potent inhibition of postprandial splanchnic hyperemia in patients with liver cirrhosis, lanreotide may be useful in the treatment of complications of portal hypertension. |
| Databáze: | OpenAIRE |
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