Real Time and Delayed Effects of Subcortical Low Intensity Focused Ultrasound
| Autor: | David W. Shattuck, Robin Blades, Norman M. Spivak, Martin M. Monti, Micah A. Johnson, Joshua A. Cain, Shakthi Visagan, Julia Sophia Crone |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male Adolescent Science Ultrasonic Therapy Blood oxygenation level dependent Biophysics Globus Pallidus Neural circuits Article Focused ultrasound 03 medical and health sciences 0302 clinical medicine Healthy volunteers Basal ganglia medicine Humans Multidisciplinary Cerebrum business.industry Neurosciences Neuropsychology Cognitive neuroscience Cognition Magnetic Resonance Imaging Brain Disorders Intensity (physics) 030104 developmental biology medicine.anatomical_structure Neurological Medicine Biomedical Imaging Female business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Scientific reports, vol 11, iss 1 Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) Scientific Reports |
| Popis: | Deep brain nuclei are integral components of large-scale circuits mediating important cognitive and sensorimotor functions. However, because they fall outside the domain of conventional non-invasive neuromodulatory techniques, their study has been primarily based on neuropsychological models, limiting the ability to fully characterize their role and to develop interventions in cases where they are damaged. To address this gap, we used the emerging technology of non-invasive low-intensity focused ultrasound (LIFU) to directly modulate left lateralized basal ganglia structures in healthy volunteers. During sonication, we observed local and distal decreases in blood oxygenation level dependent (BOLD) signal in the targeted left globus pallidus (GP) and in large-scale cortical networks. We also observed a generalized decrease in relative perfusion throughout the cerebrum following sonication. These results show, for the first time using functional MRI data, the ability to modulate deep-brain nuclei using LIFU while measuring its local and global consequences, opening the door for future applications of subcortical LIFU. |
| Databáze: | OpenAIRE |
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