Nanobubbles, cavitation, shock waves and traumatic brain injury
| Autor: | Upendra Adhikari, Ardeshir Goliaei, Max L. Berkowitz |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Shock wave
Materials science Lipid Bilayers General Physics and Astronomy Nanotechnology 02 engineering and technology 01 natural sciences 0103 physical sciences Brain Injuries Traumatic Animals Humans Physical and Theoretical Chemistry Lipid bilayer Jet (fluid) 010304 chemical physics Tight junction Cell Membrane Biological membrane Models Theoretical 021001 nanoscience & nanotechnology Biomechanical Phenomena Membrane Cavitation Biophysics 0210 nano-technology Sonoporation |
| Zdroj: | Physical chemistry chemical physics : PCCP. 18(48) |
| ISSN: | 1463-9084 |
| Popis: | Collapse of bubbles, microscopic or nanoscopic, due to their interaction with the impinging pressure wave produces a jet of particles moving in the direction of the wave. If there is a surface nearby, the high-speed jet particles hit it, and as a result damage to the surface is produced. This cavitation effect is well known and intensely studied in case of microscopic sized bubbles. It can be quite damaging to materials, including biological tissues, but it can also be beneficial when controlled, like in case of sonoporation of biological membranes for the purpose of drug delivery. Here we consider recent simulation work performed to study collapse of nanobubbles exposed to shock waves, in order to understand the detailed mechanism of the cavitation induced damage to soft materials, such as biological membranes. We also discuss the connection of the cavitation effect with the traumatic brain injury caused by blasts. Specifically, we consider possible damage to model membranes containing lipid bilayers, bilayers with embedded ion channel proteins like the ones found in neural cells and also protein assemblies found in the tight junction of the blood brain barrier. |
| Databáze: | OpenAIRE |
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