Mechanisms of cocaine-induced decreases in immune cell function
| Autor: | Barbara M. Bayer, Trisha C. Pellegrino, Keary L. Dunn |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Cellular immunity medicine.medical_specialty Hypothalamo-Hypophyseal System Lidocaine medicine.drug_class Lymphocyte Immunology Pituitary-Adrenal System Lymphocyte proliferation Lymphocyte Activation Rats Sprague-Dawley Route of administration chemistry.chemical_compound Cocaine Corticosterone Internal medicine medicine Immunology and Allergy Animals Pharmacology business.industry Local anesthetic Rats Endocrinology medicine.anatomical_structure chemistry Monoamine reuptake inhibitor business Immunosuppressive Agents medicine.drug |
| Zdroj: | International immunopharmacology. 1(4) |
| ISSN: | 1567-5769 |
| Popis: | Cocaine has previously been shown to decrease mitogen-induced T lymphocyte proliferation in rats following intravenous administration. However, in this report, it is demonstrated that central administration of cocaine (1-50 microg) had no effect on lymphocyte proliferation responses. Similarly, the quaternary derivative, cocaine methiodide, also suppressed lymphocyte proliferation only when administered peripherally (6.5 mg/kg), and not centrally (1-20 microg). These results suggest that the effects of cocaine were mediated through a peripheral mechanism. Since significant elevations in plasma corticosterone were observed with all routes of administration of cocaine, the effects of cocaine did not appear to be due entirely to activation of the HPA axis. Instead, the peripheral administration of the local anesthetic, lidocaine (5 mg/kg) or the monoamine reuptake inhibitor, RTI-55 (2-5 mg/kg), produced significant suppressive effects on proliferation. suggesting that both of these peripheral activities of cocaine may be involved in the alteration of lymphocyte responses. |
| Databáze: | OpenAIRE |
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