Transcriptional over-expression of chloride intracellular channels 3 and 4 in malignant pleural mesothelioma
| Autor: | Dimitrios E Magouliotis, Chrissi Hatzoglou, Vasiliki S. Tasiopoulou, Paschalis-Adam Molyvdas, Georgios D. Vavougios, Evgeniy I. Solenov, Sotirios G. Zarogiannis, Konstantinos I. Gourgoulianis |
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| Rok vydání: | 2015 |
| Předmět: |
Mesothelioma
Lung Neoplasms Water transport Transcription Genetic Microarray biology CLIC4 Gene Pleural Neoplasms Mesothelioma Malignant Organic Chemistry Biochemistry Interactome Gene Expression Regulation Neoplastic Computational Mathematics Chloride Channels Structural Biology CLIC4 Gene expression TGF beta signaling pathway Cancer research biology.protein Humans Gene |
| Zdroj: | Computational Biology and Chemistry. 59:111-116 |
| ISSN: | 1476-9271 |
| Popis: | Display Omitted CLIC3 and CLIC4 gene expression is induced in malignant pleural mesothelioma.CLIC3 and CLIC4 gene expressions are significantly positively associated.Functional Enrichment for GO reveals a role in EMT pathways and water transport. BackgroundChloride Intracellular Channels (CLICs) are contributing to the regulation of multiple cellular functions. CLICs have been found over-expressed in several malignancies, and therefore they are currently considered as potential drug targets. The goal of our study was to assess the gene expression levels of the CLIC's 1-6 in malignant pleural mesothelioma (MPM) as compared to controls. MethodsWe used gene expression data from a publicly available microarray dataset comparing MPM versus healthy tissue in order to investigate the differential expression profile of CLIC 1-6. False discovery rates were calculated and the interactome of the significantly differentially expressed CLICs was constructed and Functional Enrichment Analysis for Gene Ontologies (FEAGO) was performed. ResultsIn MPM, the gene expressions of CLIC3 and CLIC4 were significantly increased compared to controls (p=0.001 and p |
| Databáze: | OpenAIRE |
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