Cardiovascular disease and survival in non-small cell lung cancer: a multicenter prospective assessment

Autor: J. Cacicedo Fernández de Bobadilla, M.J. Ortiz Gordillo, M. C. Fernández Fernández, D. Herrero Rivera, J.L. Lopez Guerra, Juan Manuel Praena-Fernández, R. Bernabé Caro, J.M. Nieto-Guerrero Gómez, D. Delgado, E. Rivin del Campo
Přispěvatelé: Instituto de Salud Carlos III, Junta de Andalucía, López-Guerra, José Luis [0000-0001-6646-3751], López-Guerra, José Luis
Rok vydání: 2019
Předmět:
Adult
Male
0301 basic medicine
Cancer Research
medicine.medical_specialty
Lung Neoplasms
Heart disease
medicine.medical_treatment
Adenocarcinoma
Risk Assessment
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Non-small cell lung cancer
Carcinoma
Non-Small-Cell Lung
Diabetes mellitus
Internal medicine
Hyperlipidemia
Risk of mortality
Humans
Medicine
Prospective Studies
Risk factor
Lung cancer
Aged
Outcome
Aged
80 and over
Chemotherapy
business.industry
Thromboembolism events
General Medicine
Middle Aged
Cardiovascular disease
Prognosis
medicine.disease
respiratory tract diseases
Survival Rate
030104 developmental biology
Oncology
Cardiovascular Diseases
030220 oncology & carcinogenesis
Cohort
Carcinoma
Squamous Cell
Carcinoma
Large Cell
Female
business
Follow-Up Studies
Zdroj: Digital.CSIC. Repositorio Institucional del CSIC
instname
ISSN: 1699-3055
1699-048X
DOI: 10.1007/s12094-019-02047-5
Popis: [Purpose] Chronic inflammation contributes to cancer development via multiple mechanisms. We hypothesized that cardiovascular diseases (CVD) are also an independent risk factor for survival in non-small cell lung cancer (NSCLC).
[Materials and methods] Prospective multicenter data from 345 consecutive NSCLC patients treated from January 2013 to January 2017 were assessed. Median follow-up for all patients was 13 months (range 3–60 months). There were 109 patients with baseline heart disease (HD 32%), 149 with arterial hypertension (43%), 85 with diabetes mellitus (25%), 129 with hyperlipidemia (37%) and 45 with venous thromboembolism events (VTE 13%). A total of 289 patients (84%) were treated with platinum-based chemotherapy (CT), 300 patients (87%) received thoracic radiation therapy (RT; median radiation dose: 60 Gy [range 12–70]); and 50 (15%) patients underwent surgery.
[Results] Our cohort consisted of 305 men (88%) and 40 (12%) women, with a median age of 67 years (range 31–88 years). Seventy percent had a Karnofsky performance status (KPS) ≥ 80. Multivariate analyses showed a lower OS and higher risk of distant metastasis in patients with advanced stages (p = 0.05 and p
[Conclusions] HD and VTE are associated with a higher risk of mortality and distant metastasis in NSCLC patients. Chronic inflammation associated with CVDs could be an additional pathophysiologic factor in the development of distant metastasis.
This work was supported by grants from ISCIII (Fis: PI13/01155, PI16/02104) and Consejeria de Salud of the Junta de Andalucia (PI-0096-2012).
Databáze: OpenAIRE
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