Tamoxifen Alters TGF ‐β1/Smad Signaling in Vocal Fold Injury

Autor: Hiroki Matsushita, Shigeyuki Mukudai, Satomi Ozawa, Shota Kinoshita, Keiko Hashimoto, Mami Kaneko, Yoichiro Sugiyama, Ryan C. Branski, Shigeru Hirano
Rok vydání: 2022
Předmět:
Zdroj: The Laryngoscope.
ISSN: 1531-4995
0023-852X
DOI: 10.1002/lary.30448
Popis: Effective treatments for vocal fold fibrosis remain elusive. Tamoxifen (TAM) is a selective estrogen receptor modulator and was recently reported to have antifibrotic actions. We hypothesized that TAM inhibits vocal fold fibrosis via altered transforming growth factor beta 1 (TGF-β1) signaling. Both in vitro and in vivo approaches were employed to address this hypothesis.In vitro, vocal fold fibroblasts were treated with TAM (10TAM (10TAM has antifibrotic potential via the regulation of TGF-β1/Smad signaling in vocal fold injury. These findings provide foundational data to develop innovative therapeutic options for vocal fold fibrosis.NA Laryngoscope, 2022.
Databáze: OpenAIRE
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