The serum cytokine profiles of lymphoma-associated hemophagocytic syndrome: a comparative analysis of B-cell and T-cell/natural killer cell lymphomas
| Autor: | Takayuki Takahashi, Takashi Uchiyama, Teruyuki Takamatsu, Kenichi Nagai, Takayo Suzuki, Yasunori Ueda, Yoshiteru Konaka, Tatsuharu Ohno, Masataka Sasada |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Interleukin 2
Male medicine.medical_specialty Lymphoma B-Cell Adolescent Histiocytosis Non-Langerhans-Cell medicine.medical_treatment T cell Biology Lymphoma T-Cell Natural killer cell Internal medicine medicine Humans Receptor B cell Aged Aged 80 and over Hematology Interleukin-6 Tumor Necrosis Factor-alpha Middle Aged medicine.disease Lymphoma Interleukin-10 Killer Cells Natural Endocrinology medicine.anatomical_structure Cytokine Case-Control Studies Immunology Cytokines Female medicine.drug |
| Zdroj: | International journal of hematology. 77(3) |
| ISSN: | 0925-5710 |
| Popis: | To elucidate the differences in pathogenesis between lymphoma-associated hemophagocytic syndromes (LAHS) of the T-cell/ natural killer cell (T/NK) and B-cell (B) types, we comparatively analyzed the clinical features and serum cytokine profiles of 33 patients with LAHS registered in the Kyoto University Hematology/Oncology Study Group. The serum cytokine levels of each patient group (B-LAHS versus T/NK-LAHS) were expressed as the ratio of the median to the upper normal values of the respective cytokines and were as follows: 19.05 versus 13.99 for soluble interleukin 2 (IL-2) receptor, 0.67 versus 0.67 for granulocyte-macrophage colony-stimulating factor (GM-CSF), 0.64 versus 1.26 for G-CSF, 5.70 versus 3.61 for M-CSF, 1.54 versus 3.39 for interferon gamma (IFN-gamma), 13.17 versus 1.17 for IL-6, 6.88 versus 1.58 for tumor necrosis factor alpha (TNF-alpha), 0.71 versus 0.41 for IL-1beta, 1.99 versus 0.21 for IL-12, and 105.32 versus 29.65 for IL-10. The serum levels of IL-6, TNF-alpha, and IL-10 were significantly higher in the B-LAHS group, whereas those of IFN-y were significantly lower. These differences between the 2 groups may reflect a difference in the pathogenesis Higher serum levels of IL-6, TNF-alpha, and IL-10 may be derived at least partly from neoplastic B-cells themselves In addition, the extremely high serum levels of IL-10 suggest that a compensatory anti-inflammatory process may operate in both groups and give rise to a profound immunosuppressive state and a poor outcome. |
| Databáze: | OpenAIRE |
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