Short article
| Autor: | Daniel W. Hommes, Gary L. Norman, Zakera Shums, Floris A. van Gaalen, Michael Mahler, Johan J. van der Reijden, E. W. Nivine Levarht, Leendert A. Trouw, Hein W. Verspaget, Andrea E. van der Meulen-de Jong, Sanne J.H. Van Erp, Désirée van der Heijde, Marije K. Verheul |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Peptides Cyclic Gastroenterology Inflammatory bowel disease 03 medical and health sciences 0302 clinical medicine Crohn Disease Predictive Value of Tests Rheumatoid Factor Seroepidemiologic Studies Internal medicine medicine Humans Rheumatoid factor Serologic Tests Autoantibodies Netherlands 030203 arthritis & rheumatology Hepatology biology business.industry Smoking Case-control study Autoantibody Anti–citrullinated protein antibody Middle Aged medicine.disease digestive system diseases Immunoglobulin A Immunoglobulin M Case-Control Studies Rheumatoid arthritis biology.protein Biomarker (medicine) Colitis Ulcerative Female 030211 gastroenterology & hepatology Joint Diseases Antibody business Biomarkers |
| Zdroj: | European Journal of Gastroenterology and Hepatology |
| ISSN: | 0954-691X |
| DOI: | 10.1097/meg.0000000000000805 |
| Popis: | OBJECTIVE Biomarkers that are associated with future progression to rheumatoid arthritis (RA) and joint destruction have been discovered previously in patients with arthralgia. The present study examined these RA biomarkers in inflammatory bowel disease (IBD) patients with arthropathies. PATIENTS AND METHODS Sera from 155 IBD patients with and 99 IBD patients without arthropathies were analyzed for immunoglobulin (Ig) M rheumatoid factor (RF), IgA-RF, anti-cyclic citrullinated peptide 2, anti-cyclic citrullinated peptide 3.1, and anti-carbamylated protein antibody positivity using enzyme-linked immunosorbent assays. The prevalence of the autoantibodies in the IBD patients was compared with the prevalence in RA patients. RESULTS No differences were found in biomarker positivity between IBD patients with and without arthropathies. Significantly more biomarker positivity (P |
| Databáze: | OpenAIRE |
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