Histological and Biochemical Investigation of the Effects of Low Intensity Pulsed Ultrasound on Orthodontic Tooth Movement
| Autor: | Sevinc Inan, Mine Geçgelen Cesur, Afra Alkan, Fevziye Burcu Sirin, Mehmet Dincer Bilgin, Ergun Cem Koken, Tuna Onal, Gokhan Cesur |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty biology business.industry Ultrasound General Medicine Low-intensity pulsed ultrasound Bone remodeling Vascular endothelial growth factor chemistry.chemical_compound Endocrinology chemistry Osteoprotegerin RANKL Health Care Sciences and Services Internal medicine medicine biology.protein Immunohistochemistry Orthodontic treatment low intensity pulsed ultrasound tooth movement Sağlık Bilimleri ve Hizmetleri business Type I collagen |
| Zdroj: | Volume: 11, Issue: 1 119-125 Konuralp Medical Journal |
| ISSN: | 1309-3878 |
| Popis: | Objective: The aim of this study is to investigate the effects of low intensity pulsed ultrasound on orthodontic tooth movement in rats. Methods: For this study, 40 12-week-old adult male Wistar albino rats from the Animal Laboratory at Adnan Menderes University, Faculty of Medicine, were used. Rats were divided into four groups of ten. Group 1 was the untreated control group. In group 2, an orthodontic spring was used to move teeth. In groups 3 and 4, orthodontic treatment was combined with low intensity pulsed ultrasound at 16 J/cm2 or 48 J/cm2, respectively, for 14 days. Tooth movement was measured on day 14. Serum bone alkaline phosphatase (BALP) and C-telopeptide of type I collagen (CTX-I) levels were analyzed biochemically. The number of osteoclasts, osteoblasts and inflammatory cells, capillary density and new bone formation was determined histologically. Receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin (OPG), vascular endothelial growth factor (VGEF) and transforming growth factor-β (TGF-β) were assessed using immunohistochemical staining. Results: BALP and CTX-I levels in group 4 were significantly higher than for group 1. Tooth movement and the number of osteoclasts, inflammatory cells, and capillary density in group 4 were significantly greater than for group 2. The intensity levels of RANKL and OPG in group 4 were significantly greater than for group 2. Conclusion: Ultrasound is noninvasive application and a promising therapy for accelerating bone remodeling during orthodontic tooth movement. |
| Databáze: | OpenAIRE |
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