Controlling the Adsorption and Release of Ocular Drugs in Metal-Organic Frameworks: Effect of Polar Functional Groups
| Autor: | J. Farrando-Pérez, G. Martinez-Navarrete, J. Gandara-Loe, S. Reljic, A. Garcia-Ripoll, E. Fernandez, J. Silvestre-Albero |
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| Přispěvatelé: | Universidad de Alicante. Departamento de Química Inorgánica, Universidad de Alicante. Instituto Universitario de Materiales, Materiales Avanzados |
| Rok vydání: | 2022 |
| Předmět: |
Science & Technology
Metal–organic frameworks Polar functional groups Nitrogen Dioxide IN-VITRO SERIES MOFS Inorganic Chemistry Chemistry DELIVERY Pharmaceutical Preparations GLAUCOMA Release Brimonidine Tartrate Physical Sciences UIO-66 Ocular drugs Chemistry Inorganic & Nuclear Humans BRIMONIDINE TARTRATE Adsorption Physical and Theoretical Chemistry Metal-Organic Frameworks |
| Zdroj: | RUA. Repositorio Institucional de la Universidad de Alicante Universidad de Alicante (UA) |
| ISSN: | 1520-510X |
| Popis: | A series of UiO-66 materials with different functional groups (−H, −NH2, and −NO2) have been evaluated for the adsorption and release of a common ocular drug such as brimonidine tartrate. UiO-66 samples were synthesized under solvothermal conditions and activated by solvent exchange with ethanol. Experimental results suggest that the incorporation of surface functionalities gives rise to the development of structural defects (missing linker defects) but without altering the basic topology of the UiO-66 framework. These defects improve the adsorption performance of the parent metal–organic framework (MOF), while the bulkier functionalities infer slower release kinetics, with the associated benefits for prolonged delivery of brimonidine. Among the evaluated MOFs, defective UiO-66-NO2 can be proposed as the most promising candidate due to the combination of a larger brimonidine volumetric uptake (680 mg/cm3), a prolonged delivery (period of up to 25 days), a small particle size, and a larger instability. Contrariwise, at high concentrations UiO-66-NO2 has higher toxicity toward human retinal pigment epithelium cells (ARPE-19) compared to the pure and NH2-functionalized UiO-66. Authors would like to acknowledge financial support from the Ministerio de Ciencia e Innovación (Project PID2019-108453GB-C21), H2020 (Project MSCA-RISE-2016/NanoMed) and Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital (Project CIPROM/2021/022). |
| Databáze: | OpenAIRE |
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