The Long-Term Impact of High Levels of Alpha-Melanocyte-Stimulating Hormone in Energy Balance Among Obese Adolescents
| Autor: | Sofia Emanuelle de Castro Ferreira Vicente, Sergio Tufik, Marco Túlio de Mello, Ana Claudia Pelissari Kravchychyn, Aline de Piano Ganen, Ana Raimunda Dâmaso, Patrícia Leão da Silva, Yasmin Alaby Martins Ferreira, Raquel Munhoz da Silveira Campos, Deborah Cristina Landi Masquio, Lila Missae Oyama, Lian Tock, Flávia Campos Corgosinho |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Pediatric Obesity medicine.medical_specialty Adolescent Medicine (miscellaneous) 030209 endocrinology & metabolism Physical exercise Energy homeostasis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Weight loss Orexigenic Internal medicine Weight Loss Humans Medicine Neuropeptide Y Exercise Melanins Hypothalamic Hormones Nutrition and Dietetics business.industry Neuropeptide Y receptor alpha-Melanocyte-stimulating hormone Exercise Therapy Pituitary Hormones 030104 developmental biology Endocrinology chemistry alpha-MSH Female medicine.symptom Energy Metabolism business Body mass index Thermogenesis hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Annals of Nutrition and Metabolism. 72:279-286 |
| ISSN: | 1421-9697 0250-6807 |
| Popis: | Background: Deregulation of orexigenic and anorexigenic pathways occurs among adolescents with obesity. Alpha-melanocyte-stimulating hormone (α-MSH) is a key catabolic mediator of energy homeostasis and an important anorexigenic neuropeptide in the control of energy balance and thermogenesis. However, it was not well explored if α-MSH can modulate long-term weight loss therapy responses in a dependent manner according to its concentration. Our hypothesis is that a high α-MSH concentration at baseline promotes better modulation of anorexigenic/orexigenic pathways in obese adolescents. Methods: One hundred ten post-pubertal obese adolescents (body mass index >95th percentile) were submitted to 1 year of interdisciplinary therapy (clinical, nutritional, psychological, physical exercise, and physiotherapy support). Body composition and plasma levels of α-MSH, neuropeptide Y (NPY), melanin-concentrating hormone, and agouti-related peptide (AgRP) were measured before and after therapy. The volunteers were grouped on the basis of Tertiles of α-MSH concentration: Low (1.57 ng/mL). Significance was set as p < 0.05. Results: The treatment promoted a significant improvement in body adiposity and fat free mass for all groups. It is important to note that only in the high α-MSH group, a significant increase of the α-MSH/NPY ratio and decrease NPY/AgRP ratio post treatment were observed. Conclusion: The high α-MSH concentration promotes better modulation of anorexigenic/orexigenic pathways in obese adolescents following long-term weight loss therapy and this is important in clinical practice. |
| Databáze: | OpenAIRE |
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