Impact of the Number of Cores on the Prostate Cancer Detection Rate in Men Undergoing in-Bore Magnetic Resonance Imaging–Guided Targeted Biopsies
| Autor: | Debora Z Recchimuzzi, Yin Xi, Donglu Xie, Alberto Diaz de Leon, Daniel N. Costa, Neil M. Rofsky, Heng Chen, Ivan Pedrosa, Naveen Subramanian, Kenneth Goldberg |
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| Rok vydání: | 2020 |
| Předmět: |
Image-Guided Biopsy
Male Prostate biopsy 030218 nuclear medicine & medical imaging Lesion 03 medical and health sciences Prostate cancer 0302 clinical medicine Prostate Biopsy medicine Humans Radiology Nuclear Medicine and imaging Aged Retrospective Studies medicine.diagnostic_test business.industry Prostatic Neoplasms Magnetic resonance imaging Retrospective cohort study Middle Aged medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Detection rate medicine.symptom Nuclear medicine business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Computer Assisted Tomography. 45:203-209 |
| ISSN: | 1532-3145 0363-8715 |
| DOI: | 10.1097/rct.0000000000001115 |
| Popis: | Objective To determine the incremental detection rate of clinically significant prostate cancer (csPCa) provided by sequential cores during in-bore magnetic resonance imaging (MRI)-guided prostate biopsies. Methods Single-center, retrospective interpretation of prospectively acquired data in men without previous diagnosis of csPCa who underwent in-bore MRI-guided prostate biopsy between May 2017 and December 2019. Endpoints included detection of csPCa (grade group [GG] ≥ 2) and rate of GG upgrade provided by additional cores. Descriptive statistics presented as mean and standard deviation for the continuous variables, and frequency and percentage for the categorical variables. Results Four hundred and forty-three men with 747 lesions met eligibility criteria. Clinically significant prostate cancer was detected in 43.1% (322/747) of the biopsied lesions and GG 2 PCa or greater was identified by the first core in 78.3% (252/322) of them. On a per-core basis, cores 2, 3, 4, and 5 found new csPCa in 6% (42/744), 4% (26/719), 1% (2/137), and 0% (0/11) of the cases. Core biopsy 2, 3, 4, and 5 resulted in GG upgrade in 12% (91/744), 7% (49/719), 7% (9/137), and 0% (0/11) of the lesions, respectively. Each additional core was associated with a mean increase of 5 minutes in the duration of the biopsy. Conclusions In men undergoing in-bore MRI-guided prostate biopsies, 3 targeted cores per lesion provide an optimal trade-off between detection of clinically significant tumors and biopsy duration. |
| Databáze: | OpenAIRE |
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