Does the postcoital test predict pregnancy in WHO II anovulatory women?
| Autor: | Ben W.J. Mol, Nienke S. Weiss, Minke van der Velde, Job van der Palen, Jur Oosterhuis, Eugenie M. Kaaijk, Fulco van der Veen, Marleen Nahuis, Peter G.A. Hompes, Madelon van Wely |
|---|---|
| Přispěvatelé: | Faculty of Behavioural, Management and Social Sciences, Obstetrics and gynaecology, APH - Health Behaviors & Chronic Diseases, Graduate School, Amsterdam Reproduction & Development (AR&D), Center for Reproductive Medicine, Amsterdam Public Health, Obstetrics and Gynaecology |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Pregnancy Rate Pregnancy Tests medicine.medical_treatment IR-100007 Clomiphene Anovulation 03 medical and health sciences 0302 clinical medicine Primary outcome Ovulation Induction Pregnancy medicine Humans Prospective Studies 030212 general & internal medicine Prospective cohort study Netherlands Gynecology 030219 obstetrics & reproductive medicine business.industry Hazard ratio METIS-316220 Obstetrics and Gynecology Fertility Agents Female Postcoital test medicine.disease Pregnancy rate Treatment Outcome Reproductive Medicine Female Ovulation induction business |
| Zdroj: | European journal of obstetrics and gynaecology and reproductive biology, 199, 127-131. Elsevier Nahuis, M J, Weiss, N S, Van der Velde, M, Oosterhuis, J J E, Hompes, P G A, Kaaijk, E M, van der Palen, J, van der Veen, F, Mol, B W J & van Wely, M 2016, ' Does the postcoital test predict pregnancy in WHO II anovulatory women? A prospective cohort study ', European Journal of Obstetrics and Gynecology and Reproductive Biology, vol. 199, pp. 127-31 . https://doi.org/10.1016/j.ejogrb.2016.01.005 European Journal of Obstetrics and Gynecology and Reproductive Biology, 199, 127-31. Elsevier Ireland Ltd European journal of obstetrics, gynecology, and reproductive biology, 199, 127-131. Elsevier Ireland Ltd |
| ISSN: | 0301-2115 |
| Popis: | OBJECTIVE: To assess the capacity of the postcoital test (PCT) to predict pregnancy in WHO II anovulatory women who are ovulatory on clomiphene citrate (CC). In these women, an abnormal PCT result could be associated with lower pregnancy chances, but this has never been proven or refuted.STUDY DESIGN: Prospective cohort study was performed between December 2009 and September 2012 for all women who started ovulation induction with CC in one university clinic and two teaching hospitals in the Netherlands. A PCT was performed in one of the first three ovulatory cycles. Ovulation induction with CC was continued for at least six cycles. The PCT was judged to be positive if at least one progressive motile spermatozo was seen in one of five high power fields at 400× magnification. The primary outcome was time to ongoing pregnancy, within six ovulatory cycles.RESULTS: In 152 women the PCT was performed. 135 women had a reliable, well-timed PCT. The ongoing pregnancy rate was 44/107 (41%) for a positive and 10/28 (36%) for a negative PCT. The hazard rate for ongoing pregnancy was 1.3 (95% CI 0.64-2.5) for a positive versus a negative PCT. Thirty five of 77 (46%) women with clear mucus had an ongoing pregnancy versus 12 of 45 (27%) women in whom the mucus was not clear (HR 2.0; 95% CI 1.02-3.84, p=0.04).CONCLUSION: The present study suggests that the outcome of the postcoital test in women with WHO-II anovulation that undergo ovulation induction with CC does not have a large effect on ongoing pregnancy chances over time. |
| Databáze: | OpenAIRE |
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