Autophagy: novel insights into therapeutic target of electroacupuncture against cerebral ischemia/ reperfusion injury
| Autor: | Song-Bai Yang, Wei Tao, Zhi-Gang Mei, Zhitao Feng, Ya-Guang Huang, Jin-Feng Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Programmed cell death autophagy Electroacupuncture medicine.medical_treatment Ischemia Review Pharmacology Neuroprotection lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine Developmental Neuroscience electroacupuncture medicine LC3 Beclin1 nerve regeneration PI3K/AKT/mTOR pathway lcsh:Neurology. Diseases of the nervous system business.industry Autophagy p62 medicine.disease cerebral ischemia/reperfusion injury 030104 developmental biology mTOR neuroprotection neural regeneration Electroacupuncture Therapy business Reperfusion injury 030217 neurology & neurosurgery |
| Zdroj: | Neural Regeneration Research, Vol 14, Iss 6, Pp 954-961 (2019) Neural Regeneration Research |
| ISSN: | 1673-5374 |
| Popis: | Electroacupuncture is known as an effective adjuvant therapy in ischemic cerebrovascular disease. However, its underlying mechanisms remain unclear. Studies suggest that autophagy, which is essential for cell survival and cell death, is involved in cerebral ischemia reperfusion injury and might be modulate by electroacupuncture therapy in key ways. This paper aims to provide novel insights into a therapeutic target of electroacupuncture against cerebral ischemia/reperfusion injury from the perspective of autophagy. Here we review recent studies on electroacupuncture regulation of autophagy-related markers such as UNC-51-like kinase-1 complex, Beclin1, microtubule-associated protein-1 light chain 3, p62, and autophagosomes for treating cerebral ischemia/reperfusion injury. The results of these studies show that electroacupuncture may affect the initiation of autophagy, vesicle nucleation, expansion and maturation of autophagosomes, as well as fusion and degradation of autophagolysosomes. Moreover, studies indicate that electroacupuncture probably modulates autophagy by activating the mammalian target of the rapamycin signaling pathway. This review thus indicates that autophagy is a therapeutic target of electroacupuncture treatment against ischemic cerebrovascular diseases. |
| Databáze: | OpenAIRE |
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